UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (Transitional epithelial response protein 1)
1_MAASQ 6_ VLGEK 11_ INILS 16_ GETVK 21_ AGDRD 26_ PLGND 31_ CPEQD 36_ RLPQR 41_ SWRQK 46_ CASYV 51_ LALRP 56_ WSFSA 61_ SLTPV 66_ ALGSA 71_ LAYRS 76_ HGVLD 81_ PRLLV 86_ GCAVA 91_ VLAVH 96_ GAGNL 101_ VNTYY 106_ DFSKG 111_ IDHKK 116_ SDDRT 121_ LVDRI 126_ LEPQD 131_ VVRFG 136_ VFLYT 141_ LGCVC 146_ AACLY 151_ YLSPL 156_ KLEHL 161_ ALIYF 166_ GGLSG 171_ SFLYT 176_ GGIGF 181_ KYVAL 186_ GDLII 191_ LITFG 196_ PLAVM 201_ FAYAI 206_ QVGSL 211_ AIFPL 216_ VYAIP 221_ LALST 226_ EAILH 231_ SNNTR 236_ DMESD 241_ REAGI 246_ VTLAI 251_ LIGPT 256_ FSYIL 261_ YNTLL 266_ FLPYL 271_ VFSIL 276_ ATHCT 281_ ISLAL 286_ PLLTI 291_ PMAFS 296_ LERQF 301_ RSQAF 306_ NKLPQ 311_ RTAKL 316_ NLLLG 321_ LFYVF 326_ GIILA 331_PAGSL
1: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10 (PubMed:20953171, PubMed:23374346). MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development (PubMed:20953171). Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4 (PubMed:20953171). Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system (PubMed:23374346). Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (PubMed:23374346)