Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)
1_MGLQL 6_ RALLG 11_ AFGRW 16_ TLRLG 21_ PRPSC 26_ SPRMA 31_ GNAEP 36_ PPAGA 41_ ACPQD 46_ RRSCS 51_ GRAGG 56_ DRVWE 61_ DGEHP 66_ AKKLK 71_ SGGDE 76_ ERREK 81_ PPKRK 86_ IVLLM 91_ AYSGK 96_ GYHGM 101_ QRNVG 106_ SSQFK 111_ TIEDD 116_ LVSAL 121_ VRSGC 126_ IPENH 131_ GEDMR 136_ KMSFQ 141_ RCART 146_ DKGVS 151_ AAGQV 156_ VSLKV 161_ WLIDD 166_ ILEKI 171_ NSHLP 176_ SHIRI 181_ LGLKR 186_ VTGGF 191_ NSKNR 196_ CDART 201_ YCYLL 206_ PTFAF 211_ AHKDR 216_ DVQDE 221_ TYRLS 226_ AETLQ 231_ QVNRL 236_ LACYK 241_ GTHNF 246_ HNFTS 251_ QKGPQ 256_ DPSAC 261_ RYILE 266_ MYCEE 271_ PFVRE 276_ GLEFA 281_ VIRVK 286_ GQSFM 291_ MHQIR 296_ KMVGL 301_ VVAIV 306_ KGYAP 311_ ESVLE 316_ RSWGT 321_ EKVDV 326_ PKAPG 331_ LGLVL 336_ ERVHF 341_ EKYNQ 346_ RFGND 351_ GLHEP 356_ LDWAQ 361_ EEGKV 366_ AAFKE 371_ EHIYP 376_ TIIGT 381_ ERDER 386_ SMAQW 391_ LSTLP 396_ IHNFS 401_ ATALT 406_ AGGTG 411_ AKVPS 416_ PLEGS 421_EGDGD
1: Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:15772074, PubMed:24722331). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:24722331). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:24722331)