FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1)
1_MAGGE 6_ DRGDG 11_ EPVSV 16_ VTVRV 21_ QYLED 26_ TDPFA 31_ CANFP 36_ EPRRA 41_ PTCSL 46_ DGALP 51_ LGAQI 56_ PAVHR 61_ LLGAP 66_ LKLED 71_ CALQV 76_ SPSGY 81_ YLDTE 86_ LSLEE 91_ QREML 96_ EGFYE 101_ EISKG 106_ RKPTL 111_ ILRTQ 116_ LSVRV 121_ NAILE 126_ KLYSS 131_ SGPEL 136_ RRSLF 141_ SLKQI 146_ FQEDK 151_ DLVPE 156_ FVHSE 161_ GLSCL 166_ IRVGA 171_ AADHN 176_ YQSYI 181_ LRALG 186_ QLMLF 191_ VDGML 196_ GVVAH 201_ SDTIQ 206_ WLYTL 211_ CASLS 216_ RLVVK 221_ TALKL 226_ LLVFV 231_ EYSEN 236_ NAPLF 241_ IRAVN 246_ SVAST 251_ TGAPP 256_ WANLV 261_ SILEE 266_ KNGAD 271_ PELLV 276_ YTVTL 281_ INKTL 286_ AALPD 291_ QDSFY 296_ DVTDA 301_ LEQQG 306_ MEALV 311_ QRHLG 316_ TAGTD 321_ VDLRT 326_ QLVLY 331_ ENALK 336_ LEDGD 341_ IEEAP 346_ GAGGR 351_ RERRK 356_ PSSEE 361_ GKRSR 366_ RSLEG 371_ GGCPA 376_ RAPEP 381_ GPTGP 386_ ASPVG 391_ PTSST 396_ GPALL 401_ TGPAS 406_ SPVGP 411_ PSGLQ 416_ ASVNL 421_ FPTIS 426_ VAPSA 431_ DTSSE 436_ RSIYK 441_ ARFLE 446_ NVAAA 451_ ETEKQ 456_ VALAQ 461_ GRAET 466_ LAGAM 471_ PNEAG 476_ GHPDA 481_ RQLWD 486_ SPETA 491_ PAART 496_ PQSPA 501_ PCVLL 506_ RAQRS 511_ LAPEP 516_ KEPLI 521_ PASPK 526_ AEPIW 531_ ELPTR 536_ APRLS 541_ IGDLD 546_ FSDLG 551_ EDEDQ 556_ DMLNV 561_ ESVEA 566_ GKDIP 571_ APSPP 576_ LPLLS 581_ GVPPP 586_ PPLPP 591_ PPPIK 596_ GPFPP 601_ PPPLP 606_ LAAPL 611_ PHSVP 616_ DSSAL 621_ PTKRK 626_ TVKLF 631_ WRELK 636_ LAGGH 641_ GVSAS 646_ RFGPC 651_ ATLWA 656_ SLDPV 661_ SVDTA 666_ RLEHL 671_ FESRA 676_ KEVLP 681_ SKKAG 686_ EGRRT 691_ MTTVL 696_ DPKRS 701_ NAINI 706_ GLTTL 711_ PPVHV 716_ IKAAL 721_ LNFDE 726_ FAVSK 731_ DGIEK 736_ LLTMM 741_ PTEEE 746_ RQKIE 751_ EAQLA 756_ NPDIP 761_ LGPAE 766_ NFLMT 771_ LASIG 776_ GLAAR 781_ LQLWA 786_ FKLDY 791_ DSMER 796_ EIAEP 801_ LFDLK 806_ VGMEQ 811_ LVQNA 816_ TFRCI 821_ LATLL 826_ AVGNF 831_ LNGSQ 836_ SSGFE 841_ LSYLE 846_ KVSEV 851_ KDTVR 856_ RQSLL 861_ HHLCS 866_ LVLQT 871_ RPESS 876_ DLYSE 881_ IPALT 886_ RCAKV 891_ DFEQL 896_ TENLG 901_ QLERR 906_ SRAAE 911_ ESLRS 916_ LAKHE 921_ LAPAL 926_ RARLT 931_ HFLDQ 936_ CARRV 941_ AMLRI 946_ VHRRV 951_ CNRFH 956_ AFLLY 961_ LGYTP 966_ QAARE 971_ VRIMQ 976_ FCHTL 981_ REFAL 986_ EYRTC 991_ RERVL 996_ QQQQK 1001_ QATYR 1006_ ERNKT 1011_ RGRMI 1016_ TETEK 1021_ FSGVA 1026_ GEAPS 1031_ NPSVP 1036_ VAVSS 1041_ GPGRG 1046_ DADSH 1051_ ASMKS 1056_ LLTSR 1061_ PEDTT 1066_ HNRRS 1071_ RGMVQ 1076_ SSSPI 1081_ MPTVG 1086_ PSTAS 1091_ PEEPP 1096_ GSSLP 1101_ SDTSD 1106_ EIMDL 1111_ LVQSV 1116_ TKSSP 1121_ RALAA 1126_ RERKR 1131_ SRGNR 1136_ KSLRR 1141_ TLKSG 1146_ LGDDL 1151_ VQALG 1156_LSKGP
1: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing