Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)
1_MAGNC 6_ GARGA 11_ LSAHT 16_ LLFDL 21_ PPALL 26_ GELCA 31_ VLDSC 36_ DGALG 41_ WRGLA 46_ ERLSS 51_ SWLDV 56_ RHIEK 61_ YVDQG 66_ KSGTR 71_ ELLWS 76_ WAQKN 81_ KTIGD 86_ LLQVL 91_ QEMGH 96_ RRAIH 101_ LITNY 106_ GAVLS 111_ PSEKS 116_ YQEGG 121_ FPNIL 126_ FKETA 131_ NVTVD 136_ NVLIP 141_ EHNEK 146_ GILLK 151_ SSISF 156_ QNIIE 161_ GTRNF 166_ HKDFL 171_ IGEGE 176_ IFEVY 181_ RVEIQ 186_ NLTYA 191_ VKLFK 196_ QEKKM 201_ QCKKH 206_ WKRFL 211_ SELEV 216_ LLLFH 221_ HPNIL 226_ ELAAY 231_ FTETE 236_ KFCLI 241_ YPYMR 246_ NGTLF 251_ DRLQC 256_ VGDTA 261_ PLPWH 266_ IRIGI 271_ LIGIS 276_ KAIHY 281_ LHNVQ 286_ PCSVI 291_ CGSIS 296_ SANIL 301_ LDDQF 306_ QPKLT 311_ DFAMA 316_ HFRSH 321_ LEHQS 326_ CTINM 331_ TSSSS 336_ KHLWY 341_ MPEEY 346_ IRQGK 351_ LSIKT 356_ DVYSF 361_ GIVIM 366_ EVLTG 371_ CRVVL 376_ DDPKH 381_ IQLRD 386_ LLREL 391_ MEKRG 396_ LDSCL 401_ SFLDK 406_ KVPPC 411_ PRNFS 416_ AKLFC 421_ LAGRC 426_ AATRA 431_ KLRPS 436_ MDEVL 441_ NTLES 446_ TQASL 451_ YFAED 456_ PPTSL 461_ KSFRC 466_ PSPLF 471_ LENVP 476_ SIPVE 481_ DDESQ 486_ NNNLL 491_ PSDEG 496_ LRIDR 501_ MTQKT 506_ PFECS 511_ QSEVM 516_ FLSLD 521_ KKPES 526_ KRNEE 531_ ACNMP 536_ SSSCE 541_ ESWFP 546_ KYIVP 551_ SQDLR 556_ PYKVN 561_ IDPSS 566_ EAPGH 571_ SCRSR 576_ PVESS 581_ CSSKF 586_ SWDEY 591_EQYKK
1: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383)