Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
1_MSGST 6_ QPVAQ 11_ TWRAT 16_ EPRYP 21_ PHSLS 26_ YPVQI 31_ ARTHT 36_ DVGLL 41_ EYQHH 46_ SRDYA 51_ SHLSP 56_ GSIIQ 61_ PQRRR 66_ PSLLS 71_ EFQPG 76_ NERSQ 81_ ELHLR 86_ PESHS 91_ YLPEL 96_ GKSEM 101_ EFIES 106_ KRPRL 111_ ELLPD 116_ PLLRP 121_ SPLLA 126_ TGQPA 131_ GSEDL 136_ TKDRS 141_ LTGKL 146_ EPVSP 151_ PSPPH 156_ TDPEL 161_ ELVPP 166_ RLSKE 171_ ELIQN 176_ MDRVD 181_ REITM 186_ VEQQI 191_ SKLKK 196_ KQQQL 201_ EEEAA 206_ KPPEP 211_ EKPVS 216_ PPPIE 221_ SKHRS 226_ LVQII 231_ YDENR 236_ KKAEA 241_ AHRIL 246_ EGLGP 251_ QVELP 256_ LYNQP 261_ SDTRQ 266_ YHENI 271_ KINQA 276_ MRKKL 281_ ILYFK 286_ RRNHA 291_ RKQWE 296_ QKFCQ 301_ RYDQL 306_ MEAWE 311_ KKVER 316_ IENNP 321_ RRRAK 326_ ESKVR 331_ EYYEK 336_ QFPEI 341_ RKQRE 346_ LQERM 351_ QSRVG 356_ QRGSG 361_ LSMSA 366_ ARSEH 371_ EVSEI 376_ IDGLS 381_ EQENL 386_ EKQMR 391_ QLAVI 396_ PPMLY 401_ DADQQ 406_ RIKFI 411_ NMNGL 416_ MADPM 421_ KVYKD 426_ RQVMN 431_ MWSEQ 436_ EKETF 441_ REKFM 446_ QHPKN 451_ FGLIA 456_ SFLER 461_ KTVAE 466_ CVLYY 471_ YLTKK 476_ NENYK 481_ SLVRR 486_ SYRRR 491_ GKSQQ 496_ QQQQQ 501_ QQQQQ 506_ QQQQQ 511_ PMPRS 516_ SQEEK 521_ DEKEK 526_ EKEAE 531_ KEEEK 536_ PEVEN 541_ DKEDL 546_ LKEKT 551_ DDTSG 556_ EDNDE 561_ KEAVA 566_ SKGRK 571_ TANSQ 576_ GRRKG 581_ RITRS 586_ MANEA 591_ NSEEA 596_ ITPQQ 601_ SAELA 606_ SMELN 611_ ESSRW 616_ TEEEM 621_ ETAKK 626_ GLLEH 631_ GRNWS 636_ AIARM 641_ VGSKT 646_ VSQCK 651_ NFYFN 656_ YKKRQ 661_ NLDEI 666_ LQQHK 671_ LKMEK 676_ ERNAR 681_ RKKKK 686_ APAAA 691_ SEEAA 696_ FPPVV 701_ EDEEM 706_ EASGV 711_ SGNEE 716_ EMVEE 721_ AEALH 726_ ASGNE 731_ VPRGE 736_ CSGPA 741_ TVNNS 746_ SDTES 751_ IPSPH 756_ TEAAK 761_ DTGQN 766_ GPKPP 771_ ATLGA 776_ DGPPP 781_ GPPTP 786_ PPEDI 791_ PAPTE 796_ PTPAS 801_ EATGA 806_ PTPPP 811_ APPSP 816_ SAPPP 821_ VVPKE 826_ EKEEE 831_ TAAAP 836_ PVEEG 841_ EEQKP 846_ PAAEE 851_ LAVDT 856_ GKAEE 861_ PVKSE 866_ CTEEA 871_ EEGPA 876_ KGKDA 881_ EAAEA 886_ TAEGA 891_ LKAEK 896_ KEGGS 901_ GRATT 906_ AKSSG 911_ APQDS 916_ DSSAT 921_ CSADE 926_ VDEAE 931_ GGDKN 936_ RLLSP 941_ RPSLL 946_ TPTGD 951_ PRANA 956_ SPQKP 961_ LDLKQ 966_ LKQRA 971_ AAIPP 976_ IQVTK 981_ VHEPP 986_ REDAA 991_ PTKPA 996_ PPAPP 1001_ PPQNL 1006_ QPESD 1011_ APQQP 1016_ GSSPR 1021_ GKSRS 1026_ PAPPA 1031_ DKEAF 1036_ AAEAQ 1041_ KLPGD 1046_ PPCWT 1051_ SGLPF 1056_ PVPPR 1061_ EVIKA 1066_ SPHAP 1071_ DPSAF 1076_ SYAPP 1081_ GHPLP 1086_ LGLHD 1091_ TARPV 1096_ LPRPP 1101_ TISNP 1106_ PPLIS 1111_ SAKHP 1116_ SVLER 1121_ QIGAI 1126_ SQGMS 1131_ VQLHV 1136_ PYSEH 1141_ AKAPV 1146_ GPVTM 1151_ GLPLP 1156_ MDPKK 1161_ LAPFS 1166_ GVKQE 1171_ QLSPR 1176_ GQAGP 1181_ PESLG 1186_ VPTAQ 1191_ EASVL 1196_ RGTAL 1201_ GSVPG 1206_ GSITK 1211_ GIPST 1216_ RVPSD 1221_ SAITY 1226_ RGSIT 1231_ HGTPA 1236_ DVLYK 1241_ GTITR 1246_ IIGED 1251_ SPSRL 1256_ DRGRE 1261_ DSLPK 1266_ GHVIY 1271_ EGKKG 1276_ HVLSY 1281_ EGGMS 1286_ VTQCS 1291_ KEDGR 1296_ SSSGP 1301_ PHETA 1306_ APKRT 1311_ YDMME 1316_ GRVGR 1321_ AISSA 1326_ SIEGL 1331_ MGRAI 1336_ PPERH 1341_ SPHHL 1346_ KEQHH 1351_ IRGSI 1356_ TQGIP 1361_ RSYVE 1366_ AQEDY 1371_ LRREA 1376_ KLLKR 1381_ EGTPP 1386_ PPPPS 1391_ RDLTE 1396_ AYKTQ 1401_ ALGPL 1406_ KLKPA 1411_ HEGLV 1416_ ATVKE 1421_ AGRSI 1426_ HEIPR 1431_ EELRH 1436_ TPELP 1441_ LAPRP 1446_ LKEGS 1451_ ITQGT 1456_ PLKYD 1461_ TGAST 1466_ TGSKK 1471_ HDVRS 1476_ LIGSP 1481_ GRTFP 1486_ PVHPL 1491_ DVMAD 1496_ ARALE 1501_ RACYE 1506_ ESLKS 1511_ RPGTA 1516_ SSSGG 1521_ SIARG 1526_ APVIV 1531_ PELGK 1536_ PRQSP 1541_ LTYED 1546_ HGAPF 1551_ AGHLP 1556_ RGSPV 1561_ TTREP 1566_ TPRLQ 1571_ EGSLS 1576_ SSKAS 1581_ QDRKL 1586_ TSTPR 1591_ EIAKS 1596_ PHSTV 1601_ PEHHP 1606_ HPISP 1611_ YEHLL 1616_ RGVSG 1621_ VDLYR 1626_ SHIPL 1631_ AFDPT 1636_ SIPRG 1641_ IPLDA 1646_ AAAYY 1651_ LPRHL 1656_ APNPT 1661_ YPHLY 1666_ PPYLI 1671_ RGYPD 1676_ TAALE 1681_ NRQTI 1686_ INDYI 1691_ TSQQM 1696_ HHNAA 1701_ TAMAQ 1706_ RADML 1711_ RGLSP 1716_ RESSL 1721_ ALNYA 1726_ AGPRG 1731_ IIDLS 1736_ QVPHL 1741_ PVLVP 1746_ PTPGT 1751_ PATAM 1756_ DRLAY 1761_ LPTAP 1766_ QPFSS 1771_ RHSSS 1776_ PLSPG 1781_ GPTHL 1786_ TKPTT 1791_ TSSSE 1796_ RERDR 1801_ DRERD 1806_ RDRER 1811_ EKSIL 1816_ TSTTT 1821_ VEHAP 1826_ IWRPG 1831_ TEQSS 1836_ GSSGG 1841_ GGGSS 1846_ SRPAS 1851_ HSHAH 1856_ QHSPI 1861_ SPRTQ 1866_ DALQQ 1871_ RPSVL 1876_ HNTGM 1881_ KGIIT 1886_ AVEPS 1891_ TPTVL 1896_ RSTST 1901_ SSPVR 1906_ PAATF 1911_ PPATH 1916_ CPLGG 1921_ TLDGV 1926_ YPTLM 1931_ EPVLL 1936_ PKEAP 1941_ RVARP 1946_ ERPRA 1951_ DTGHA 1956_ FLAKP 1961_ PARSG 1966_ LEPAS 1971_ SPSKG 1976_ SEPRP 1981_ LVPPV 1986_ SGHAT 1991_ IARTP 1996_ AKNLA 2001_ PHHAS 2006_ PDPPA 2011_ PPASA 2016_ SDPHR 2021_ EKTQS 2026_ KPFSI 2031_ QELEL 2036_ RSLGY 2041_ HGSSY 2046_ SPEGV 2051_ EPVSP 2056_ VSSPS 2061_ LTHDK 2066_ GLPKH 2071_ LEELD 2076_ KSHLE 2081_ GELRP 2086_ KQPGP 2091_ VKLGG 2096_ EAAHL 2101_ PHLRP 2106_ LPESQ 2111_ PSSSP 2116_ LLQTA 2121_ PGVKG 2126_ HQRVV 2131_ TLAQH 2136_ ISEVI 2141_ TQDYT 2146_ RHHPQ 2151_ QLSAP 2156_ LPAPL 2161_ YSFPG 2166_ ASCPV 2171_ LDLRR 2176_ PPSDL 2181_ YLPPP 2186_ DHGAP 2191_ ARGSP 2196_ HSEGG 2201_ KRSPE 2206_ PNKTS 2211_ VLGGG 2216_ EDGIE 2221_ PVSPP 2226_ EGMTE 2231_ PGHSR 2236_ SAVYP 2241_ LLYRD 2246_ GEQTE 2251_ PSRMG 2256_ SKSPG 2261_ NTSQP 2266_ PAFFS 2271_ KLTES 2276_ NSAMV 2281_ KSKKQ 2286_ EINKK 2291_ LNTHN 2296_ RNEPE 2301_ YNISQ 2306_ PGTEI 2311_ FNMPA 2316_ ITGTG 2321_ LMTYR 2326_ SQAVQ 2331_ EHAST 2336_ NMGLE 2341_ AIIRK 2346_ ALMGK 2351_ YDQWE 2356_ ESPPL 2361_ SANAF 2366_ NPLNA 2371_ SASLP 2376_ AAMPI 2381_ TAADG 2386_ RSDHT 2391_ LTSPG 2396_ GGGKA 2401_ KVSGR 2406_ PSSRK 2411_ AKSPA 2416_ PGLAS 2421_ GDRPP 2426_ SVSSV 2431_ HSEGD 2436_ CNRRT 2441_ PLTNR 2446_ VWEDR 2451_ PSSAG 2456_ STPFP 2461_ YNPLI 2466_ MRLQA 2471_ GVMAS 2476_ PPPPG 2481_ LPAGS 2486_ GPLAG 2491_ PHHAW 2496_ DEEPK 2501_ PLLCS 2506_QYETL
1: Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024)
2: Isoform 1 and isoform 4 have different affinities for different nuclear receptors
3: Isoform 1 and isoform 4 have different affinities for different nuclear receptors