Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)
1_MGTKA 6_ QVERK 11_ LLCLF 16_ ILAIL 21_ LCSLA 26_ LGSVT 31_ VHSSE 36_ PEVRI 41_ PENNP 46_ VKLSC 51_ AYSGF 56_ SSPRV 61_ EWKFD 66_ QGDTT 71_ RLVCY 76_ NNKIT 81_ ASYED 86_ RVTFL 91_ PTGIT 96_ FKSVT 101_ REDTG 106_ TYTCM 111_ VSEEG 116_ GNSYG 121_ EVKVK 126_ LIVLV 131_ PPSKP 136_ TVNIP 141_ SSATI 146_ GNRAV 151_ LTCSE 156_ QDGSP 161_ PSEYT 166_ WFKDG 171_ IVMPT 176_ NPKST 181_ RAFSN 186_ SSYVL 191_ NPTTG 196_ ELVFD 201_ PLSAS 206_ DTGEY 211_ SCEAR 216_ NGYGT 221_ PMTSN 226_ AVRME 231_ AVERN 236_ VGVIV 241_ AAVLV 246_ TLILL 251_ GILVF 256_ GIWFA 261_ YSRGH 266_ FDRTK 271_ KGTSS 276_ KKVIY 281_ SQPSA 286_ RSEGE 291_FKQTS
1: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840)
2: (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1
3: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa