Gene name: RFNG

Uniprot entry:

Q9Y644

Protein names:

Beta-1,3-N-acetylglucosaminyltransferase radical fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

Protein sequence:

1_MSRAR 6_ GALCR 11_ ACLAL 16_ AAALA 21_ ALLLL 26_ PLPLP 31_ RAPAP 36_ ARTPA 41_ PAPRA 46_ PPSRP 51_ AAPSL 56_ RPDDV 61_ FIAVK 66_ TTRKN 71_ HGPRL 76_ RLLLR 81_ TWISR 86_ ARQQT 91_ FIFTD 96_ GDDPE 101_ LELQG 106_ GDRVI 111_ NTNCS 116_ AVRTR 121_ QALCC 126_ KMSVE 131_ YDKFI 136_ ESGRK 141_ WFCHV 146_ DDDNY 151_ VNARS 156_ LLHLL 161_ SSFSP 166_ SQDVY 171_ LGRPS 176_ LDHPI 181_ EATER 186_ VQGGR 191_ TVTTV 196_ KFWFA 201_ TGGAG 206_ FCLSR 211_ GLALK 216_ MSPWA 221_ SLGSF 226_ MSTAE 231_ QVRLP 236_ DDCTV 241_ GYIVE 246_ GLLGA 251_ RLLHS 256_ PLFHS 261_ HLENL 266_ QRLPP 271_ DTLLQ 276_ QVTLS 281_ HGGPE 286_ NPHNV 291_ VNVAG 296_ GFSLH 301_ QDPTR 306_ FKSIH 311_ CLLYP 316_ DTDWC 321_ PRQKQ 326_GAPTS

Protein annotations

Protein functions:

1: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis