Spindlin-1 (Ovarian cancer-related protein) (Spindlin1)
1_MKTPF 6_ GKTPG 11_ QRSRA 16_ DAGHA 21_ GVSAN 26_ MMKKR 31_ TSHKK 36_ HRSSV 41_ GPSKP 46_ VSQPR 51_ RNIVG 56_ CRIQH 61_ GWKEG 66_ NGPVT 71_ QWKGT 76_ VLDQV 81_ PVNPS 86_ LYLIK 91_ YDGFD 96_ CVYGL 101_ ELNKD 106_ ERVSA 111_ LEVLP 116_ DRVAT 121_ SRISD 126_ AHLAD 131_ TMIGK 136_ AVEHM 141_ FETED 146_ GSKDE 151_ WRGMV 156_ LARAP 161_ VMNTW 166_ FYITY 171_ EKDPV 176_ LYMYQ 181_ LLDDY 186_ KEGDL 191_ RIMPD 196_ SNDSP 201_ PAERE 206_ PGEVV 211_ DSLVG 216_ KQVEY 221_ AKEDG 226_ SKRTG 231_ MVIHQ 236_ VEAKP 241_ SVYFI 246_ KFDDD 251_ FHIYV 256_YDLVK
1: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity)