Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1) (3-OST-3A) (Heparan sulfate 3-O-sulfotransferase 3A1) (h3-OST-3A)
1_MAPPG 6_ PASAL 11_ STSAE 16_ PLSRS 21_ IFRKF 26_ LLMLC 31_ SLLTS 36_ LYVFY 41_ CLAER 46_ CQTLS 51_ GPVVG 56_ LSGGG 61_ EEAGA 66_ PGGGV 71_ LAGGP 76_ RELAV 81_ WPAAA 86_ QRKRL 91_ LQLPQ 96_ WRRRR 101_ PPAPR 106_ DDGEE 111_ AAWEE 116_ ESPGL 121_ SGGPG 126_ GSGAG 131_ STVAE 136_ APPGT 141_ LALLL 146_ DEGSK 151_ QLPQA 156_ IIIGV 161_ KKGGT 166_ RALLE 171_ FLRVH 176_ PDVRA 181_ VGAEP 186_ HFFDR 191_ SYDKG 196_ LAWYR 201_ DLMPR 206_ TLDGQ 211_ ITMEK 216_ TPSYF 221_ VTREA 226_ PARIS 231_ AMSKD 236_ TKLIV 241_ VVRDP 246_ VTRAI 251_ SDYTQ 256_ TLSKR 261_ PDIPT 266_ FESLT 271_ FKNRT 276_ AGLID 281_ TSWSA 286_ IQIGI 291_ YAKHL 296_ EHWLR 301_ HFPIR 306_ QMLFV 311_ SGERL 316_ ISDPA 321_ GELGR 326_ VQDFL 331_ GLKRI 336_ ITDKH 341_ FYFNK 346_ TKGFP 351_ CLKKA 356_ EGSSR 361_ PHCLG 366_ KTKGR 371_ THPEI 376_ DREVV 381_ RRLRE 386_ FYRPF 391_ NLKFY 396_ QMTGH 401_DFGWD
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:10608887, PubMed:15304505, PubMed:9988768). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:15304505, PubMed:9988768). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:10520990)