KICSTOR complex protein kaptin (Actin-associated protein 2E4)
1_MMGEA 6_ AVAAG 11_ PCPLR 16_ EDSFT 21_ RFSSQ 26_ SNVYG 31_ LAGGA 36_ GGRGE 41_ LLAAT 46_ LKGKV 51_ LGFRY 56_ QDLRQ 61_ KIRPV 66_ AKELQ 71_ FNYIP 76_ VDAEI 81_ VSIDT 86_ FNKSP 91_ PKRGL 96_ VVGIT 101_ FIKDS 106_ GDKGS 111_ PFLNI 116_ YCDYE 121_ PGSEY 126_ NLDSI 131_ AQSCL 136_ NLELQ 141_ FTPFQ 146_ LCHAE 151_ VQVGD 156_ QLETV 161_ FLLSG 166_ NDPAI 171_ HLYKE 176_ NEGLH 181_ QFEEQ 186_ PVENL 191_ FPELT 196_ NLTSS 201_ VLWLD 206_ VHNFP 211_ GTSRR 216_ LSALG 221_ CQSGY 226_ VRVAH 231_ VDQRS 236_ REVLQ 241_ MWSVL 246_ QDGPI 251_ SRVIV 256_ FSLSA 261_ AKETK 266_ DRPLQ 271_ DEYSV 276_ LVASM 281_ LEPAV 286_ VYRDL 291_ LNRGL 296_ EDQLL 301_ LPGSD 306_ QFDSV 311_ LCSLV 316_ TDVDL 321_ DGRPE 326_ VLVAT 331_ YGQEL 336_ LCYKY 341_ RGPES 346_ GLPEA 351_ QHGFH 356_ LLWQR 361_ SFSSP 366_ LLAMA 371_ HVDLT 376_ GDGLQ 381_ ELAVV 386_ SLKGV 391_ HILQH 396_ SLIQA 401_ SELVL 406_ TRLRH 411_ QVEQR 416_ RRRLQ 421_ GLEDG 426_ AGAGP 431_AENAA
1: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose