Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)
1_MEKWY 6_ LMTVV 11_ VLIGL 16_ TVRWT 21_ VSLNS 26_ YSGAG 31_ KPPMF 36_ GDYEA 41_ QRHWQ 46_ EITFN 51_ LPVKQ 56_ WYFNS 61_ SDNNL 66_ QYWGL 71_ DYPPL 76_ TAYHS 81_ LLCAY 86_ VAKFI 91_ NPDWI 96_ ALHTS 101_ RGYES 106_ QAHKL 111_ FMRTT 116_ VLIAD 121_ LLIYI 126_ PAVVL 131_ YCCCL 136_ KEIST 141_ KKKIA 146_ NALCI 151_ LLYPG 156_ LILID 161_ YGHFQ 166_ YNSVS 171_ LGFAL 176_ WGVLG 181_ ISCDC 186_ DLLGS 191_ LAFCL 196_ AINYK 201_ QMELY 206_ HALPF 211_ FCFLL 216_ GKCFK 221_ KGLKG 226_ KGFVL 231_ LVKLA 236_ CIVVA 241_ SFVLC 246_ WLPFF 251_ TEREQ 256_ TLQVL 261_ RRLFP 266_ VDRGL 271_ FEDKV 276_ ANIWC 281_ SFNVF 286_ LKIKD 291_ ILPRH 296_ IQLIM 301_ SFCST 306_ FLSLL 311_ PACIK 316_ LILQP 321_ SSKGF 326_ KFTLV 331_ SCALS 336_ FFLFS 341_ FQVHE 346_ KSILL 351_ VSLPV 356_ CLVLS 361_ EIPFM 366_ STWFL 371_ LVSTF 376_ SMLPL 381_ LLKDE 386_ LLMPS 391_ VVTTM 396_ AFFIA 401_ CVTSF 406_ SIFEK 411_ TSEEE 416_ LQLKS 421_ FSISV 426_ RKYLP 431_ CFTFL 436_ SRIIQ 441_ YLFLI 446_ SVITM 451_ VLLTL 456_ MTVTL 461_ DPPQK 466_ LPDLF 471_ SVLVC 476_ FVSCL 481_ NFLFF 486_ LVYFN 491_ IIIMW 496_ DSKSG 501_RNQKK
1: Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Man(9)GlcNAc(2)-PP-Dol to produce Glc(1)Man(9)GlcNAc(2)-PP-Dol. Glc(1)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG8, the following enzyme in the biosynthetic pathway