Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)
1_MLKKF 6_ DKKDE 11_ ESGGG 16_ SNPFQ 21_ HLEKS 26_ AVLQE 31_ ARVFN 36_ ETPIN 41_ PRKCA 46_ HILTK 51_ ILYLI 56_ NQGEH 61_ LGTTE 66_ ATEAF 71_ FAMTK 76_ LFQSN 81_ DPTLR 86_ RMCYL 91_ TIKEM 96_ SCIAE 101_ DVIIV 106_ TSSLT 111_ KDMTG 116_ KEDNY 121_ RGPAV 126_ RALCQ 131_ ITDST 136_ MLQAI 141_ ERYMK 146_ QAIVD 151_ KVPSV 156_ SSSAL 161_ VSSLH 166_ LLKCS 171_ FDVVK 176_ RWVNE 181_ AQEAA 186_ SSDNI 191_ MVQYH 196_ ALGLL 201_ YHVRK 206_ NDRLA 211_ VNKMI 216_ SKVTR 221_ HGLKS 226_ PFAYC 231_ MMIRV 236_ ASKQL 241_ EEEDG 246_ SRDSP 251_ LFDFI 256_ ESCLR 261_ NKHEM 266_ VVYEA 271_ ASAIV 276_ NLPGC 281_ SAKEL 286_ APAVS 291_ VLQLF 296_ CSSPK 301_ AALRY 306_ AAVRT 311_ LNKVA 316_ MKHPS 321_ AVTAC 326_ NLDLE 331_ NLVTD 336_ SNRSI 341_ ATLAI 346_ TTLLK 351_ TGSES 356_ SIDRL 361_ MKQIS 366_ SFMSE 371_ ISDEF 376_ KVVVV 381_ QAISA 386_ LCQKY 391_ PRKHA 396_ VLMNF 401_ LFTML 406_ REEGG 411_ FEYKR 416_ AIVDC 421_ IISII 426_ EENSE 431_ SKETG 436_ LSHLC 441_ EFIED 446_ CEFTV 451_ LATRI 456_ LHLLG 461_ QEGPK 466_ TTNPS 471_ KYIRF 476_ IYNRV 481_ VLEHE 486_ EVRAG 491_ AVSAL 496_ AKFGA 501_ QNEEM 506_ LPSIL 511_ VLLKR 516_ CVMDD 521_ DNEVR 526_ DRATF 531_ YLNVL 536_ EQKQK 541_ ALNAG 546_ YILNG 551_ LTVSI 556_ PGLER 561_ ALQQY 566_ TLEPS 571_ EKPFD 576_ LKSVP 581_ LATAP 586_ MAEQR 591_ TESTP 596_ ITAVK 601_ QPEKV 606_ AATRQ 611_ EIFQE 616_ QLAAV 621_ PEFRG 626_ LGPLF 631_ KSSPE 636_ PVALT 641_ ESETE 646_ YVIRC 651_ TKHTF 656_ TNHMV 661_ FQFDC 666_ TNTLN 671_ DQTLE 676_ NVTVQ 681_ MEPTE 686_ AYEVL 691_ CYVPA 696_ RSLPY 701_ NQPGT 706_ CYTLV 711_ ALPKE 716_ DPTAV 721_ ACTFS 726_ CMMKF 731_ TVKDC 736_ DPTTG 741_ ETDDE 746_ GYEDE 751_ YVLED 756_ LEVTV 761_ ADHIQ 766_ KVMKL 771_ NFEAA 776_ WDEVG 781_ DEFEK 786_ EETFT 791_ LSTIK 796_ TLEEA 801_ VGNIV 806_ KFLGM 811_ HPCER 816_ SDKVP 821_ DNKNT 826_ HTLLL 831_ AGVFR 836_ GGHDI 841_ LVRSR 846_ LLLLD 851_ TVTMQ 856_ VTARS 861_ LEELP 866_VDIIL
1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity)