Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1)
1_MELPS 6_ GPGPE 11_ RLFDS 16_ HRLPG 21_ DCFLL 26_ LVLLL 31_ YAPVG 36_ FCLLV 41_ LRLFL 46_ GIHVF 51_ LVSCA 56_ LPDSV 61_ LRRFV 66_ VRTMC 71_ AVLGL 76_ VARQE 81_ DSGLR 86_ DHSVR 91_ VLISN 96_ HVTPF 101_ DHNIV 106_ NLLTT 111_ CSTPL 116_ LNSPP 121_ SFVCW 126_ SRGFM 131_ EMNGR 136_ GELVE 141_ SLKRF 146_ CASTR 151_ LPPTP 156_ LLLFP 161_ EEEAT 166_ NGREG 171_ LLRFS 176_ SWPFS 181_ IQDVV 186_ QPLTL 191_ QVQRP 196_ LVSVT 201_ VSDAS 206_ WVSEL 211_ LWSLF 216_ VPFTV 221_ YQVRW 226_ LRPVH 231_ RQLGE 236_ ANEEF 241_ ALRVQ 246_ QLVAK 251_ ELGQT 256_ GTRLT 261_ PADKA 266_ EHMKR 271_ QRHPR 276_ LRPQS 281_ AQSSF 286_ PPSPG 291_ PSPDV 296_ QLATL 301_ AQRVK 306_ EVLPH 311_ VPLGV 316_ IQRDL 321_ AKTGC 326_ VDLTI 331_ TNLLE 336_ GAVAF 341_ MPEDI 346_ TKGTQ 351_ SLPTA 356_ SASKF 361_ PSSGP 366_ VTPQP 371_ TALTF 376_ AKSSW 381_ ARQES 386_ LQERK 391_ QALYE 396_ YARRR 401_FTERR
1: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:21857022). Induces lipid droplet clustering (PubMed:24039768). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:21127063, PubMed:23223569). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703)
2: (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles