Solute carrier family 22 member 7 (Novel liver transporter) (Organic anion transporter 2) (hOAT2)
1_MGFEE 6_ LLEQV 11_ GGFGP 16_ FQLRN 21_ VALLA 26_ LPRVL 31_ LPLHF 36_ LLPIF 41_ LAAVP 46_ AHRCA 51_ LPGAP 56_ ANFSH 61_ QDVWL 66_ EAHLP 71_ REPDG 76_ TLSSC 81_ LRFAY 86_ PQALP 91_ NTTLG 96_ EERQS 101_ RGELE 106_ DEPAT 111_ VPCSQ 116_ GWEYD 121_ HSEFS 126_ STIAT 131_ ESQWD 136_ LVCEQ 141_ KGLNR 146_ AASTF 151_ FFAGV 156_ LVGAV 161_ AFGYL 166_ SDRFG 171_ RRRLL 176_ LVAYV 181_ STLVL 186_ GLASA 191_ ASVSY 196_ VMFAI 201_ TRTLT 206_ GSALA 211_ GFTII 216_ VMPLE 221_ LEWLD 226_ VEHRT 231_ VAGVL 236_ SSTFW 241_ TGGVM 246_ LLALV 251_ GYLIR 256_ DWRWL 261_ LLAVT 266_ LPCAP 271_ GILSL 276_ WWVPE 281_ SARWL 286_ LTQGH 291_ VKEAH 296_ RYLLH 301_ CARLN 306_ GRPVC 311_ EDSFS 316_ QEAVS 321_ KVAAG 326_ ERVVR 331_ RPSYL 336_ DLFRT 341_ PRLRH 346_ ISLCC 351_ VVVWF 356_ GVNFS 361_ YYGLS 366_ LDVSG 371_ LGLNV 376_ YQTQL 381_ LFGAV 386_ ELPSK 391_ LLVYL 396_ SVRYA 401_ GRRLT 406_ QAGTL 411_ LGTAL 416_ AFGTR 421_ LLVSS 426_ DMKSW 431_ STVLA 436_ VMGKA 441_ FSEAA 446_ FTTAY 451_ LFTSE 456_ LYPTV 461_ LRQTG 466_ MGLTA 471_ LVGRL 476_ GGSLA 481_ PLAAL 486_ LDGVW 491_ LSLPK 496_ LTYGG 501_ IALLA 506_ AGTAL 511_ LLPET 516_ RQAQL 521_ PETIQ 526_ DVERK 531_ SAPTS 536_ LQEEE 541_MPMKQ
1: Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:11327718, PubMed:18216183, PubMed:21446918, PubMed:28945155). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:11327718, PubMed:25904762). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (PubMed:11327718, PubMed:18216183, PubMed:26377792, PubMed:28945155). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (PubMed:18216183, PubMed:26377792). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood (PubMed:21446918). Involved in renal secretion and possible reabsorption of creatinine (PubMed:25904762, PubMed:28945155). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate (PubMed:11327718, PubMed:26377792). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (PubMed:26377792)
2: Non functional transporter
3: Involved in the uptake of prostaglandin F2-alpha (PGF2-alpha)