Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)
1_MARGG 6_ DTGCT 11_ GPSET 16_ SASGA 21_ AAIAL 26_ PGLEG 31_ PATDA 36_ QCQTL 41_ PLTVL 46_ KSRSP 51_ SPRSL 56_ PPALS 61_ CPPPQ 66_ PAMLE 71_ HLSSL 76_ PTQMD 81_ YKGQK 86_ LAEQM 91_ FQGII 96_ LFSAI 101_ VGFIY 106_ GYVAE 111_ QFGWT 116_ VYIVM 121_ AGFAF 126_ SCLLT 131_ LPPWP 136_ IYRRH 141_ PLKWL 146_ PVQES 151_ STDDK 156_ KPGER 161_KIKRH
1: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Dispensable for SPC enzymatic activity (By similarity)
2: (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV) (PubMed:24009510, PubMed:27383988, PubMed:29593046). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1 (PubMed:27383988, PubMed:29593046). In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2 (PubMed:24009510)