EP300-interacting inhibitor of differentiation 1 (21 kDa pRb-associated protein) (CREBBP/EP300 inhibitory protein 1) (E1A-like inhibitor of differentiation 1) (EID-1)
1_MSEMA 6_ ELSEL 11_ YEESS 16_ DLQMD 21_ VMPGE 26_ GDLPQ 31_ MEVGS 36_ GSREL 41_ SLRPS 46_ RSGAQ 51_ QLEEE 56_ GPMEE 61_ EEAQP 66_ MAAPE 71_ GKRSL 76_ ANGPN 81_ AGEQP 86_ GQVAG 91_ ADFES 96_ EDEGE 101_ EFDDW 106_ EDDYD 111_ YPEEE 116_ QLSGA 121_ GYRVS 126_ AALEE 131_ ADKMF 136_ LRTRE 141_ PALDG 146_ GFQMH 151_ YEKTP 156_ FDQLA 161_ FIEEL 166_ FSLMV 171_ VNRLT 176_ EELGC 181_DEIID
1: Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms