AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin)
1_MPYLG 6_ SEDVV 11_ KELKK 16_ ALCNP 21_ HIQAD 26_ RLRYR 31_ NVIQR 36_ VIRYM 41_ TQGLD 46_ MSGVF 51_ MEMVK 56_ ASATV 61_ DIVQK 66_ KLVYL 71_ YMCTY 76_ APLKP 81_ DLALL 86_ AINTL 91_ CKDCS 96_ DPNPM 101_ VRGLA 106_ LRSMC 111_ SLRMP 116_ GVQEY 121_ IQQPI 126_ LNGLR 131_ DKASY 136_ VRRVA 141_ VLGCA 146_ KMHNL 151_ HGDSE 156_ VDGAL 161_ VNELY 166_ SLLRD 171_ QDPIV 176_ VVNCL 181_ RSLEE 186_ ILKQE 191_ GGVVI 196_ NKPIA 201_ HHLLN 206_ RMSKL 211_ DQWGQ 216_ AEVLN 221_ FLLRY 226_ QPRSE 231_ EELFD 236_ ILNLL 241_ DSFLK 246_ SSSPG 251_ VVMGA 256_ TKLFL 261_ ILAKM 266_ FPHVQ 271_ TDVLV 276_ RVKGP 281_ LLAAC 286_ SSESR 291_ ELCFV 296_ ALCHV 301_ RQILH 306_ SLPGH 311_ FSSHY 316_ KKFFC 321_ SYSEP 326_ HYIKL 331_ QKVEV 336_ LCELV 341_ NDENV 346_ QQVLE 351_ ELRGY 356_ CTDVS 361_ ADFAQ 366_ AAIFA 371_ IGGIA 376_ RTYTD 381_ QCVQI 386_ LTELL 391_ GLRQE 396_ HITTV 401_ VVQTF 406_ RDLVW 411_ LCPQC 416_ TEAVC 421_ QALPG 426_ CEENI 431_ QDSEG 436_ KQALI 441_ WLLGV 446_ HGERI 451_ PNAPY 456_ VLEDF 461_ VENVK 466_ SETFP 471_ AVKME 476_ LLTAL 481_ LRLFL 486_ SRPAE 491_ CQDML 496_ GRLLY 501_ YCIEE 506_ EKDMA 511_ VRDRG 516_ LFYYR 521_ LLLVG 526_ IDEVK 531_ RILCS 536_ PKSDP 541_ TLGLL 546_ EDPAE 551_ RPVNS 556_ WASDF 561_ NTLVP 566_ VYGKA 571_ HWATI 576_ SKCQG 581_ AERCD 586_ PELPK 591_ TSSFA 596_ ASGPL 601_ IPEEN 606_ KERVQ 611_ ELPDS 616_ GALML 621_ VPNRQ 626_ LTADY 631_ FEKTW 636_ LSLKV 641_ AHQQV 646_ LPWRG 651_ EFHPD 656_ TLQMA 661_ LQVVN 666_ IQTIA 671_ MSRAG 676_ SRPWK 681_ AYLSA 686_ QDDTG 691_ CLFLT 696_ ELLLE 701_ PGNSE 706_ MQISV 711_ KQNEA 716_ RTETL 721_ NSFIS 726_ VLETV 731_IGTIE
1: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable)