Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)
1_MADAA 6_ SQVLL 11_ GSGLT 16_ ILSQP 21_ LMYVK 26_ VLIQV 31_ GYEPL 36_ PPTIG 41_ RNIFG 46_ RQVCQ 51_ LPGLF 56_ SYAQH 61_ IASID 66_ GRRGL 71_ FTGLT 76_ PRLCS 81_ GVLGT 86_ VVHGK 91_ VLQHY 96_ QESDK 101_ GEELG 106_ PGNVQ 111_ KEVSS 116_ SFDHV 121_ IKETT 126_ REMIA 131_ RSAAT 136_ LITHP 141_ FHVIT 146_ LRSMV 151_ QFIGR 156_ ESKYC 161_ GLCDS 166_ IITIY 171_ REEGI 176_ LGFFA 181_ GLVPR 186_ LLGDI 191_ LSLWL 196_ CNSLA 201_ YLVNT 206_ YALDS 211_ GVSTM 216_ NEMKS 221_ YSQAV 226_ TGFFA 231_ SMLTY 236_ PFVLV 241_ SNLMA 246_ VNNCG 251_ LAGGC 256_ PPYSP 261_ IYTSW 266_ IDCWC 271_ MLQKE 276_ GNMSR 281_ GNSLF 286_ FRKVP 291_ FGKTY 296_CCDLK
1: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity)