Selenoprotein K (SelK)
1_MVYIS 6_ NGQVL 11_ DSRSQ 16_ SPWRL 21_ SLITD 26_ FFWGI 31_ AEFVV 36_ LFFKT 41_ LLQQD 46_ VKKRR 51_ SYGNS 56_ SDSRY 61_ DDGRG 66_ PPGNP 71_ PRRMG 76_ RINHL 81_ RGPSP 86_PPMAG
1: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588)