Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
1_MQESQ 6_ TKSMF 11_ VSRAL 16_ EKILA 21_ DKEVK 26_ RPQHS 31_ QLRRA 36_ CQVAL 41_ DEIKA 46_ EIEKQ 51_ RLGTA 56_ APPKA 61_ NFIEA 66_ DKYFL 71_ PFELA 76_ CQSKS 81_ PRVVS 86_ TSLDC 91_ LQKLI 96_ AYGHI 101_ TGNAP 106_ DSGAP 111_ GKRLI 116_ DRIVE 121_ TICSC 126_ FQGPQ 131_ TDEGV 136_ QLQII 141_ KALLT 146_ AVTSP 151_ HIEIH 156_ EGTIL 161_ QTVRT 166_ CYNIY 171_ LASKN 176_ LINQT 181_ TAKAT 186_ LTQML 191_ NVIFT 196_ RMENQ 201_ VLQEA 206_ RELEK 211_ PIQSK 216_ PQSPV 221_ IQAAA 226_ VSPKF 231_ VRLKH 236_ SQAQS 241_ KPTTP 246_ EKTDL 251_ TNGEH 256_ ARSDS 261_ GKVST 266_ ENGDA 271_ PRERG 276_ SSLSG 281_ TDDGA 286_ QEVVK 291_ DILED 296_ VVTSA 301_ IKEAA 306_ EKHGL 311_ TEPER 316_ VLGEL 321_ ECQEC 326_ AIPPG 331_ VDENS 336_ QTNGI 341_ ADDRQ 346_ SLSSA 351_ DNLES 356_ DAQGH 361_ QVAAR 366_ FSHVL 371_ QKDAF 376_ LVFRS 381_ LCKLS 386_ MKPLG 391_ EGPPD 396_ PKSHE 401_ LRSKV 406_ VSLQL 411_ LLSVL 416_ QNAGP 421_ VFRTH 426_ EMFIN 431_ AIKQY 436_ LCVAL 441_ SKNGV 446_ SSVPD 451_ VFELS 456_ LAIFL 461_ TLLSN 466_ FKMHL 471_ KMQIE 476_ VFFKE 481_ IFLNI 486_ LETST 491_ SSFEH 496_ RWMVI 501_ QTLTR 506_ ICADA 511_ QCVVD 516_ IYVNY 521_ DCDLN 526_ AANIF 531_ ERLVN 536_ DLSKI 541_ AQGRS 546_ GHELG 551_ MTPLQ 556_ ELSLR 561_ KKGLE 566_ CLVSI 571_ LKCMV 576_ EWSKD 581_ LYVNP 586_ NHQTS 591_ LGQER 596_ LTDQE 601_ IGDGK 606_ GLDMA 611_ RRCSV 616_ TSMES 621_ TVSSG 626_ TQTTV 631_ QDDPE 636_ QFEVI 641_ KQQKE 646_ IIEHG 651_ IELFN 656_ KKPKR 661_ GIQFL 666_ QEQGM 671_ LGTSV 676_ EDIAQ 681_ FLHQE 686_ ERLDS 691_ TQVGD 696_ FLGDS 701_ ARFNK 706_ EVMYA 711_ YVDQL 716_ DFCEK 721_ EFVSA 726_ LRTFL 731_ EGFRL 736_ PGEAQ 741_ KIDRL 746_ MEKFA 751_ ARYIE 756_ CNQGQ 761_ TLFAS 766_ ADTAY 771_ VLAYS 776_ IIMLT 781_ TDLHS 786_ PQVKN 791_ KMTKE 796_ QYIKM 801_ NRGIN 806_ DSKDL 811_ PEEYL 816_ SSIYE 821_ EIEGK 826_ KIAMK 831_ ETKEL 836_ TIATK 841_ STKQN 846_ VASEK 851_ QRRLL 856_ YNLEM 861_ EQMAK 866_ TAKAL 871_ MEAVS 876_ HAKAP 881_ FTSAT 886_ HLDHV 891_ RPMFK 896_ LVWTP 901_ LLAAY 906_ SIGLQ 911_ NCDDT 916_ EVASL 921_ CLEGI 926_ RCAIR 931_ IACIF 936_ GMQLE 941_ RDAYV 946_ QALAR 951_ FSLLT 956_ ASSSI 961_ TEMKQ 966_ KNIDT 971_ IKTLI 976_ TVAHT 981_ DGNYL 986_ GNSWH 991_ EILKC 996_ ISQLE 1001_ LAQLI 1006_ GTGVK 1011_ TRYLS 1016_ GSGRE 1021_ REGSL 1026_ KGHTL 1031_ AGEEF 1036_ MGLGL 1041_ GNLVS 1046_ GGVDK 1051_ RQMAS 1056_ FQESV 1061_ GETSS 1066_ QSVVV 1071_ AVDRI 1076_ FTGST 1081_ RLDGN 1086_ AIVDF 1091_ VRWLC 1096_ AVSMD 1101_ ELASP 1106_ HHPRM 1111_ FSLQK 1116_ IVEIS 1121_ YYNMN 1126_ RIRLQ 1131_ WSRIW 1136_ HVIGD 1141_ HFNKV 1146_ GCNPN 1151_ EDVAI 1156_ FAVDS 1161_ LRQLS 1166_ MKFLE 1171_ KGELA 1176_ NFRFQ 1181_ KDFLR 1186_ PFEHI 1191_ MKKNR 1196_ SPTIR 1201_ DMAIR 1206_ CIAQM 1211_ VNSQA 1216_ ANIRS 1221_ GWKNI 1226_ FAVFH 1231_ QAASD 1236_ HDGNI 1241_ VELAF 1246_ QTTCH 1251_ IVTTI 1256_ FQHHF 1261_ PAAID 1266_ SFQDA 1271_ VKCLS 1276_ EFACN 1281_ AAFPD 1286_ TSMEA 1291_ IRLIR 1296_ FCGKY 1301_ VSERP 1306_ RVLQE 1311_ YTSDD 1316_ MNVAP 1321_ GDRVW 1326_ VRGWF 1331_ PILFE 1336_ LSCII 1341_ NRCKL 1346_ DVRTR 1351_ GLTVM 1356_ FEIMK 1361_ SYGHT 1366_ FEKHW 1371_ WQDLF 1376_ RIVFR 1381_ IFDNM 1386_ KLPEQ 1391_ LSEKS 1396_ EWMTT 1401_ TCNHA 1406_ LYAIC 1411_ DVFTQ 1416_ FYEAL 1421_ NEVLL 1426_ SDVFA 1431_ QLQWC 1436_ VKQDN 1441_ EQLAR 1446_ SGTNC 1451_ LENLV 1456_ ISNGE 1461_ KFSPE 1466_ VWDET 1471_ CNCML 1476_ DIFKT 1481_ TIPHV 1486_ LLTWR 1491_ PVGME 1496_ EDSSE 1501_ KHLDV 1506_ DLDRQ 1511_ SLSSI 1516_ DKNPS 1521_ ERGQS 1526_ QLSNP 1531_ TDDSW 1536_ KGRPY 1541_ ANQKL 1546_ FASLL 1551_ IKCVV 1556_ QLELI 1561_ QTIDN 1566_ IVFYP 1571_ ATSKK 1576_ EDAEH 1581_ MVAAQ 1586_ QDTLD 1591_ ADIHI 1596_ ETEDQ 1601_ GMYKY 1606_ MSSQH 1611_ LFKLL 1616_ DCLQE 1621_ SHSFS 1626_ KAFNS 1631_ NYEQR 1636_ TVLWR 1641_ AGFKG 1646_ KSKPN 1651_ LLKQE 1656_ TSSLA 1661_ CCLRI 1666_ LFRMY 1671_ VDENR 1676_ RDSWE 1681_ EIQQR 1686_ LLTVC 1691_ SEALA 1696_ YFITV 1701_ NSESH 1706_ REAWT 1711_ SLLLL 1716_ LLTKT 1721_ LKIND 1726_ EKFKA 1731_ HASMY 1736_ YPYLC 1741_ EIMQF 1746_ DLIPE 1751_ LRAVL 1756_ RKFFL 1761_ RIGVV 1766_ YKIWI 1771_ PEEPS 1776_QVPAA
1: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways