Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)
1_MEDLG 6_ ENTMV 11_ LSTLR 16_ SLNNF 21_ ISQRV 26_ EGGSG 31_ LDIST 36_ SAPGS 41_ LQMQY 46_ QQSMQ 51_ LEERA 56_ EQIRS 61_ KSHLI 66_ QVERE 71_ KMQME 76_ LSHKR 81_ ARVEL 86_ ERAAS 91_ TSARN 96_ YEREV 101_ DRNQE 106_ LLTRI 111_ RQLQE 116_ REAGA 121_ EEKMQ 126_ EQLER 131_ NRQCQ 136_ QNLDA 141_ ASKRL 146_ REKED 151_ SLAQA 156_ GETIN 161_ ALKGR 166_ ISELQ 171_ WSVMD 176_ QEMRV 181_ KRLES 186_ EKQEL 191_ QEQLD 196_ LQHKK 201_ CQEAN 206_ QKIQE 211_ LQASQ 216_ EARAD 221_ HEQQI 226_ KDLEQ 231_ KLSLQ 236_ EQDAA 241_ IVKNM 246_ KSELV 251_ RLPRL 256_ ERELK 261_ QLREE 266_ SAHLR 271_ EMRET 276_ NGLLQ 281_ EELEG 286_ LQRKL 291_ GRQEK 296_ MQETL 301_ VGLEL 306_ ENERL 311_ LAKLQ 316_ SWERL 321_ DQTMG 326_ LSIRT 331_ PEDLS 336_ RFVVE 341_ LQQRE 346_ LALKD 351_ KNSAV 356_ TSSAR 361_ GLEKA 366_ RQQLQ 371_ EELRQ 376_ VSGQL 381_ LEERK 386_ KRETH 391_ EALAR 396_ RLQKR 401_ VLLLT 406_ KERDG 411_ MRAIL 416_ GSYDS 421_ ELTPA 426_ EYSPQ 431_ LTRRM 436_ REAED 441_ MVQKV 446_ HSHSA 451_ EMEAQ 456_ LSQAL 461_ EELGG 466_ QKQRA 471_ DMLEM 476_ ELKML 481_ KSQSS 486_ SAEQS 491_ FLFSR 496_ EEADT 501_ LRLKV 506_ EELEG 511_ ERSRL 516_ EEEKR 521_ MLEAQ 526_ LERRA 531_ LQGDY 536_ DQSRT 541_ KVLHM 546_ SLNPT 551_ SVARQ 556_ RLRED 561_ HSQLQ 566_ AECER 571_ LRGLL 576_ RAMER 581_ GGTVP 586_ ADLEA 591_ AAASL 596_ PSSKE 601_ VAELK 606_ KQVES 611_ AELKN 616_ QRLKE 621_ VFQTK 626_ IQEFR 631_ KACYT 636_ LTGYQ 641_ IDITT 646_ ENQYR 651_ LTSLY 656_ AEHPG 661_ DCLIF 666_ KATSP 671_ SGSKM 676_ QLLET 681_ EFSHT 686_ VGELI 691_ EVHLR 696_ RQDSI 701_ PAFLS 706_ SLTLE 711_LFSRQ
1: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720)
2: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas