Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]
1_MDSRA 6_ QLWGL 11_ ALNKR 16_ RATLP 21_ HPGGS 26_ TNLKA 31_ DPEEL 36_ FTKLE 41_ KIGKG 46_ SFGEV 51_ FKGID 56_ NRTQK 61_ VVAIK 66_ IIDLE 71_ EAEDE 76_ IEDIQ 81_ QEITV 86_ LSQCD 91_ SPYVT 96_ KYYGS 101_ YLKDT 106_ KLWII 111_ MEYLG 116_ GGSAL 121_ DLLEP 126_ GPLDE 131_ TQIAT 136_ ILREI 141_ LKGLD 146_ YLHSE 151_ KKIHR 156_ DIKAA 161_ NVLLS 166_ EHGEV 171_ KLADF 176_ GVAGQ 181_ LTDTQ 186_ IKRNT 191_ FVGTP 196_ FWMAP 201_ EVIKQ 206_ SAYDS 211_ KADIW 216_ SLGIT 221_ AIELA 226_ RGEPP 231_ HSELH 236_ PMKVL 241_ FLIPK 246_ NNPPT 251_ LEGNY 256_ SKPLK 261_ EFVEA 266_ CLNKE 271_ PSFRP 276_ TAKEL 281_ LKHKF 286_ ILRNA 291_ KKTSY 296_ LTELI 301_ DRYKR 306_ WKAEQ 311_ SHDDS 316_ SSEDS 321_ DAETD 326_ GQASG 331_ GSDSG 336_ DWIFT 341_ IREKD 346_ PKNLE 351_ NGALQ 356_ PSDLD 361_ RNKMK 366_ DIPKR 371_ PFSQC 376_ LSTII 381_ SPLFA 386_ ELKEK 391_ SQACG 396_ GNLGS 401_ IEELR 406_ GAIYL 411_ AEEAC 416_ PGISD 421_ TMVAQ 426_ LVQRL 431_ QRYSL 436_SGGGT
1: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)