eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2)
1_MNKHQ 6_ KPVLT 11_ GQRFK 16_ TRKRD 21_ EKEKF 26_ EPTVF 31_ RDTLV 36_ QGLNE 41_ AGDDL 46_ EAVAK 51_ FLDST 56_ GSRLD 61_ YRRYA 66_ DTLFD 71_ ILVAG 76_ SMLAP 81_ GGTRI 86_ DDGDK 91_ TKMTN 96_ HCVFS 101_ ANEDH 106_ ETIRN 111_ YAQVF 116_ NKLIR 121_ RYKYL 126_ EKAFE 131_ DEMKK 136_ LLLFL 141_ KAFSE 146_ TEQTK 151_ LAMLS 156_ GILLG 161_ NGTLP 166_ ATILT 171_ SLFTD 176_ SLVKE 181_ GIAAS 186_ FAVKL 191_ FKAWM 196_ AEKDA 201_ NSVTS 206_ SLRKA 211_ NLDKR 216_ LLELF 221_ PVNRQ 226_ SVDHF 231_ AKYFT 236_ DAGLK 241_ ELSDF 246_ LRVQQ 251_ SLGTR 256_ KELQK 261_ ELQER 266_ LSQEC 271_ PIKEV 276_ VLYVK 281_ EEMKR 286_ NDLPE 291_ TAVIG 296_ LLWTC 301_ IMNAV 306_ EWNKK 311_ EELVA 316_ EQALK 321_ HLKQY 326_ APLLA 331_ VFSSQ 336_ GQSEL 341_ ILLQK 346_ VQEYC 351_ YDNIH 356_ FMKAF 361_ QKIVV 366_ LFYKA 371_ DVLSE 376_ EAILK 381_ WYKEA 386_ HVAKG 391_ KSVFL 396_ DQMKK 401_ FVEWL 406_ QNAEE 411_ESESE
1: Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931)