Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1)
1_MGMDL 6_ TCPFG 11_ ISPAC 16_ GAQAS 21_ WSIFG 26_ ADAAE 31_ VPGTR 36_ GHSQQ 41_ EAAMP 46_ HIPED 51_ EEPPG 56_ EPQAA 61_ QSPAG 66_ QGPPA 71_ AGVSC 76_ SPTPT 81_ IVLTG 86_ DATSP 91_ EGETD 96_ KNLAN 101_ RVHSP 106_ HKRLS 111_ HRHLK 116_ VSTAS 121_ LTSVD 126_ PAGHI 131_ IDLVN 136_ DQLPD 141_ ISISE 146_ EDKKK 151_ NLALL 156_ EEAKL 161_ VSERF 166_ LTRRG 171_ RKSRS 176_ SPGDS 181_ PSAVS 186_ PNLSP 191_ SASPT 196_ SSRSN 201_ SLTVP 206_ TPPGL 211_ DVCSG 216_ PPSPL 221_ PGAPP 226_ QQKGD 231_ EADVS 236_ SPHPG 241_ EPNVP 246_ KGLAD 251_ RKQND 256_ QRKVS 261_ QGRLA 266_ PRPPP 271_ VEKSK 276_ EIAIE 281_ QKENF 286_ DPLQY 291_ PETTP 296_ KGLAP 301_ VTNSS 306_ GKMAL 311_ NSPQP 316_ GPVES 321_ ELGKQ 326_ LLKTG 331_ WEGSP 336_ LPRSP 341_ TQDAA 346_ GVGPP 351_ ASQGR 356_ GPAGE 361_ PMGPE 366_ AGSKA 371_ ELPPT 376_ VSRPP 381_ LLRGL 386_ SWDSG 391_ PEEPG 396_ PRLQK 401_ VLAKL 406_ PLAEE 411_ EKRFA 416_ GKAGG 421_ KLAKA 426_ PGLKD 431_ FQIQV 436_ QPVRM 441_ QKLTK 446_ LREEH 451_ ILMRN 456_ QNLVG 461_ LKLPD 466_ LSEAA 471_ EQEKG 476_ LPSEL 481_ SPAIE 486_ EEESK 491_ SGLDV 496_ MPNIS 501_ DVLLR 506_ KLRVH 511_ RSLPG 516_ SAPPL 521_ TEKEV 526_ ENVFV 531_ QLSLA 536_ FRNDS 541_ YTLES 546_ RINQA 551_ ERERN 556_ LTEEN 561_ TEKEL 566_ ENFKA 571_ SITSS 576_ ASLWH 581_ HCEHR 586_ ETYQK 591_ LLEDI 596_ AVLHR 601_ LAARL 606_ SSRAE 611_ VVGAV 616_ RQEKR 621_ MSKAT 626_ EVMMQ 631_ YVENL 636_ KRTYE 641_ KDHAE 646_ LMEFK 651_ KLANQ 656_ NSSRS 661_ CGPSE 666_ DGVPR 671_ TARSM 676_ SLTLG 681_ KNMPR 686_ RRVSV 691_ AVVPK 696_ FNALN 701_ LPGQT 706_ PSSSS 711_ IPSLP 716_ ALSES 721_ PNGKG 726_ SLPVT 731_ SALPA 736_ LLENG 741_ KTNGD 746_ PDCEA 751_ SAPAL 756_ TLSCL 761_ EELSQ 766_ ETKAR 771_ MEEEA 776_ YSKGF 781_ QEGLK 786_ KTKEL 791_ QDLKE 796_ EEEEQ 801_ KSESP 806_ EEPEE 811_ VEETE 816_ EEEKG 821_ PRSSK 826_ LEELV 831_ HFLQV 836_ MYPKL 841_ CQHWQ 846_ VIWMM 851_ AAVML 856_ VLTVV 861_ LGLYN 866_ SYNSC 871_ AEQAD 876_ GPLGR 881_ STCSA 886_ AQRDS 891_ WWSSG 896_LQHEQ
1: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation (PubMed:14729908). Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity)