Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic)
1_MAAVG 6_ RVGSF 11_ GSSPP 16_ GLSST 21_ YTGGP 26_ LGNEI 31_ ASGNG 36_ GAAAG 41_ DDEDG 46_ QNLWS 51_ CILSE 56_ VSTRS 61_ RSKLP 66_ AGKNV 71_ LLLGE 76_ DGAGK 81_ TSLIR 86_ KIQGI 91_ EEYKK 96_ GRGLE 101_ YLYLN 106_ VHDED 111_ RDDQT 116_ RCNVW 121_ ILDGD 126_ LYHKG 131_ LLKFS 136_ LDAVS 141_ LKDTL 146_ VMLVV 151_ DMSKP 156_ WTALD 161_ SLQKW 166_ ASVVR 171_ EHVDK 176_ LKIPP 181_ EEMKQ 186_ MEQKL 191_ IRDFQ 196_ EYVEP 201_ GEDFP 206_ ASPQR 211_ RNTAS 216_ QEDKD 221_ DSVVL 226_ PLGAD 231_ TLTHN 236_ LGIPV 241_ LVVCT 246_ KCDAI 251_ SVLEK 256_ EHDYR 261_ DEHFD 266_ FIQSH 271_ IRKFC 276_ LQYGA 281_ ALIYT 286_ SVKEN 291_ KNIDL 296_ VYKYI 301_ VQKLY 306_ GFPYK 311_ IPAVV 316_ VEKDA 321_ VFIPA 326_ GWDND 331_ KKIGI 336_ LHENF 341_ QTLKA 346_ EDNFE 351_ DIITK 356_ PPVRK 361_ FVHEK 366_ EIMAE 371_ DDQVF 376_ LMKLQ 381_ SLLAK 386_ QPPTA 391_ AGRPV 396_ DASPR 401_ VPGGS 406_ PRTPN 411_ RSVSS 416_ NVASV 421_ SPIPA 426_ GSKKI 431_ DPNMK 436_ AGATS 441_ EGVLA 446_ NFFNS 451_ LLSKK 456_ TGSPG 461_ GPGVS 466_ GGSPA 471_ GGAGG 476_ GSSGL 481_ PPSTK 486_ KSGQK 491_ PVLDV 496_ HAELD 501_ RITRK 506_ PVTVS 511_ PTTPT 516_SPTEG
1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645)