Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)
1_MEAPE 6_ YLDLD 11_ EIDFS 16_ DDISY 21_ SVTSL 26_ KTIPE 31_ LCRRC 36_ DTQNE 41_ DRSVS 46_ SSSWN 51_ CGIST 56_ LITNT 61_ QKPTG 66_ IADVY 71_ SKFRP 76_ VKRVS 81_ PLKHQ 86_ PETLE 91_ NNESD 96_ DQKNQ 101_ KVVEY 106_ QKGGE 111_ SDLGP 116_ QPQEL 121_ GPGDG 126_ VGGPP 131_ GKSSE 136_ PSTSL 141_ GELEH 146_ YDLDM 151_ DEILD 156_ VPYIK 161_ SSQQL 166_ ASFTK 171_ VTSEK 176_ RILGL 181_ CTTIN 186_ GLSGK 191_ ACSTG 196_ SSESS 201_ SSNMA 206_ PFCVL 211_ SPVKS 216_ PHLRK 221_ ASAVI 226_ HDQHK 231_ LSTEE 236_ TEISP 241_ PLVKC 246_ GSAYE 251_ PENQS 256_ KDFLN 261_ KTFSD 266_ PHGRK 271_ VEKTT 276_ PDCQL 281_ RAFHL 286_ QSSAA 291_ ESKPE 296_ EQVSG 301_ LNRTS 306_ SQGPE 311_ ERSEY 316_ LKKVK 321_ SILNI 326_ VKEGQ 331_ ISLLP 336_ HLAAD 341_ NLDKI 346_ HDENG 351_ NNLLH 356_ IAASQ 361_ GHAEC 366_ LQHLT 371_ SLMGE 376_ DCLNE 381_ RNTEK 386_ LTPAG 391_ LAIKN 396_ GQLEC 401_ VRWMV 406_ SETEA 411_ IAELS 416_ CSKDF 421_ PSLIH 426_ YAGCY 431_ GQEKI 436_ LLWLL 441_ QFMQE 446_ QGISL 451_ DEVDQ 456_ DGNSA 461_ VHVAS 466_ QHGYL 471_ GCIQT 476_ LVEYG 481_ ANVTM 486_ QNHAG 491_ EKPSQ 496_ SAERQ 501_ GHTLC 506_ SRYLV 511_ VVETC 516_ MSLAS 521_ QVVKL 526_ TKQLK 531_ EQTVE 536_ RVTLQ 541_ NQLQQ 546_ FLEAQ 551_ KSEGK 556_ SLPSS 561_ PSSPS 566_ SPASR 571_ KSQWK 576_ SPDAD 581_ DDSVA 586_ KSKPG 591_ VQEGI 596_ QVLGS 601_ LSASS 606_ RARPK 611_ AKDED 616_ SDKIL 621_ RQLLG 626_ KEISE 631_ NVCTQ 636_ EKLSL 641_ EFQDA 646_ QASSR 651_ NSKKI 656_ PLEKR 661_ ELKLA 666_ RLRQL 671_ MQRSL 676_ SESDT 681_ DSNNS 686_ EDPKT 691_ TPVRK 696_ ADRPR 701_ PQPIV 706_ ESVES 711_ MDSAE 716_ SLHLM 721_ IKKHT 726_ LASGG 731_ RRFPF 736_ SIKAS 741_ KSLDG 746_ HSPSP 751_ TSESS 756_ EPDLE 761_ SQYPG 766_ SGSIP 771_ PNQPS 776_ GDPQQ 781_ PSPDS 786_ TAAQK 791_ VATSP 796_ KSALK 801_ SPSSK 806_ RRTSQ 811_ NLKLR 816_ VTFEE 821_ PVVQM 826_ EQPSL 831_ ELNGE 836_ KDKDK 841_ GRTLQ 846_ RTSTS 851_ NESGD 856_ QLKRP 861_ FGAFR 866_ SIMET 871_ LSGNQ 876_ NNNNN 881_ YQAAN 886_ QLKTS 891_ TLPLT 896_ SLGRK 901_ TDAKG 906_ NPASS 911_ASKGK
1: Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1