Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3)
1_MECPH 6_ LSSSV 11_ CIAPD 16_ SAKFP 21_ NGSPS 26_ SWCCS 31_ VCRSN 36_ KSPWV 41_ CLTCS 46_ SVHCG 51_ RYVNG 56_ HAKKH 61_ YEDAQ 66_ VPLTN 71_ HKKSE 76_ KQDKV 81_ QHTVC 86_ MDCSS 91_ YSTYC 96_ YRCDD 101_ FVVND 106_ TKLGL 111_ VQKVR 116_ EHLQN 121_ LENSA 126_ FTADR 131_ HKKRK 136_ LLENS 141_ TLNSK 146_ LLKVN 151_ GSTTA 156_ ICATG 161_ LRNLG 166_ NTCFM 171_ NAILQ 176_ SLSNI 181_ EQFCC 186_ YFKEL 191_ PAVEL 196_ RNGKT 201_ AGRRT 206_ YHTRS 211_ QGDNN 216_ VSLVE 221_ EFRKT 226_ LCALW 231_ QGSQT 236_ AFSPE 241_ SLFYV 246_ VWKIM 251_ PNFRG 256_ YQQQD 261_ AHEFM 266_ RYLLD 271_ HLHLE 276_ LQGGF 281_ NGVSR 286_ SAILQ 291_ ENSTL 296_ SASNK 301_ CCING 306_ ASTVV 311_ TAIFG 316_ GILQN 321_ EVNCL 326_ ICGTE 331_ SRKFD 336_ PFLDL 341_ SLDIP 346_ SQFRS 351_ KRSKN 356_ QENGP 361_ VCSLR 366_ DCLRS 371_ FTDLE 376_ ELDET 381_ ELYMC 386_ HKCKK 391_ KQKST 396_ KKFWI 401_ QKLPK 406_ VLCLH 411_ LKRFH 416_ WTAYL 421_ RNKVD 426_ TYVEF 431_ PLRGL 436_ DMKCY 441_ LLEPE 446_ NSGPE 451_ SCLYD 456_ LAAVV 461_ VHHGS 466_ GVGSG 471_ HYTAY 476_ ATHEG 481_ RWFHF 486_ NDSTV 491_ TLTDE 496_ ETVVK 501_ AKAYI 506_ LFYVE 511_HQAKA
1: Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:24196443). Required for proper progression through S phase and subsequent mitotic entry (PubMed:17980597). Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation (PubMed:28807825). Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88 (PubMed:37971847). Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1 (PubMed:24366338). Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation (PubMed:36050480)