WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)
1_MASFP 6_ PRVNE 11_ KEIVR 16_ LRTIG 21_ ELLAP 26_ AAPFD 31_ KKCGR 36_ ENWTV 41_ AFAPD 46_ GSYFA 51_ WSQGH 56_ RTVKL 61_ VPWSQ 66_ CLQNF 71_ LLHGT 76_ KNVTN 81_ SSSLR 86_ LPRQN 91_ SDGGQ 96_ KNKPR 101_ EHIID 106_ CGDIV 111_ WSLAF 116_ GSSVP 121_ EKQSR 126_ CVNIE 131_ WHRFR 136_ FGQDQ 141_ LLLAT 146_ GLNNG 151_ RIKIW 156_ DVYTG 161_ KLLLN 166_ LVDHT 171_ EVVRD 176_ LTFAP 181_ DGSLI 186_ LVSAS 191_ RDKTL 196_ RVWDL 201_ KDDGN 206_ MMKVL 211_ RGHQN 216_ WVYSC 221_ AFSPD 226_ SSMLC 231_ SVGAS 236_ KAVFL 241_ WNMDK 246_ YTMIR 251_ KLEGH 256_ HHDVV 261_ ACDFS 266_ PDGAL 271_ LATAS 276_ YDTRV 281_ YIWDP 286_ HNGDI 291_ LMEFG 296_ HLFPP 301_ PTPIF 306_ AGGAN 311_ DRWVR 316_ SVSFS 321_ HDGLH 326_ VASLA 331_ DDKMV 336_ RFWRI 341_ DEDYP 346_ VQVAP 351_ LSNGL 356_ CCAFS 361_ TDGSV 366_ LAAGT 371_ HDGSV 376_ YFWAT 381_ PRQVP 386_ SLQHL 391_ CRMSI 396_ RRVMP 401_ TQEVQ 406_ ELPIP 411_ SKLLE 416_FLSYR
1: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation