DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)
1_MPAMP 6_ SSGPG 11_ DTSSS 16_ AAERE 21_ EDRKD 26_ GEEQE 31_ EPRGK 36_ EERQE 41_ PSTTA 46_ RKVGR 51_ PGRKR 56_ KHPPV 61_ ESGDT 66_ PKDPA 71_ VISKS 76_ PSMAQ 81_ DSGAS 86_ ELLPN 91_ GDLEK 96_ RSEPQ 101_ PEEGS 106_ PAGGQ 111_ KGGAP 116_ AEGEG 121_ AAETL 126_ PEASR 131_ AVENG 136_ CCTPK 141_ EGRGA 146_ PAEAG 151_ KEQKE 156_ TNIES 161_ MKMEG 166_ SRGRL 171_ RGGLG 176_ WESSL 181_ RQRPM 186_ PRLTF 191_ QAGDP 196_ YYISK 201_ RKRDE 206_ WLARW 211_ KREAE 216_ KKAKV 221_ IAGMN 226_ AVEEN 231_ QGPGE 236_ SQKVE 241_ EASPP 246_ AVQQP 251_ TDPAS 256_ PTVAT 261_ TPEPV 266_ GSDAG 271_ DKNAT 276_ KAGDD 281_ EPEYE 286_ DGRGF 291_ GIGEL 296_ VWGKL 301_ RGFSW 306_ WPGRI 311_ VSWWM 316_ TGRSR 321_ AAEGT 326_ RWVMW 331_ FGDGK 336_ FSVVC 341_ VEKLM 346_ PLSSF 351_ CSAFH 356_ QATYN 361_ KQPMY 366_ RKAIY 371_ EVLQV 376_ ASSRA 381_ GKLFP 386_ VCHDS 391_ DESDT 396_ AKAVE 401_ VQNKP 406_ MIEWA 411_ LGGFQ 416_ PSGPK 421_ GLEPP 426_ EEEKN 431_ PYKEV 436_ YTDMW 441_ VEPEA 446_ AAYAP 451_ PPPAK 456_ KPRKS 461_ TAEKP 466_ KVKEI 471_ IDERT 476_ RERLV 481_ YEVRQ 486_ KCRNI 491_ EDICI 496_ SCGSL 501_ NVTLE 506_ HPLFV 511_ GGMCQ 516_ NCKNC 521_ FLECA 526_ YQYDD 531_ DGYQS 536_ YCTIC 541_ CGGRE 546_ VLMCG 551_ NNNCC 556_ RCFCV 561_ ECVDL 566_ LVGPG 571_ AAQAA 576_ IKEDP 581_ WNCYM 586_ CGHKG 591_ TYGLL 596_ RRRED 601_ WPSRL 606_ QMFFA 611_ NNHDQ 616_ EFDPP 621_ KVYPP 626_ VPAEK 631_ RKPIR 636_ VLSLF 641_ DGIAT 646_ GLLVL 651_ KDLGI 656_ QVDRY 661_ IASEV 666_ CEDSI 671_ TVGMV 676_ RHQGK 681_ IMYVG 686_ DVRSV 691_ TQKHI 696_ QEWGP 701_ FDLVI 706_ GGSPC 711_ NDLSI 716_ VNPAR 721_ KGLYE 726_ GTGRL 731_ FFEFY 736_ RLLHD 741_ ARPKE 746_ GDDRP 751_ FFWLF 756_ ENVVA 761_ MGVSD 766_ KRDIS 771_ RFLES 776_ NPVMI 781_ DAKEV 786_ SAAHR 791_ ARYFW 796_ GNLPG 801_ MNRPL 806_ ASTVN 811_ DKLEL 816_ QECLE 821_ HGRIA 826_ KFSKV 831_ RTITT 836_ RSNSI 841_ KQGKD 846_ QHFPV 851_ FMNEK 856_ EDILW 861_ CTEME 866_ RVFGF 871_ PVHYT 876_ DVSNM 881_ SRLAR 886_ QRLLG 891_ RSWSV 896_ PVIRH 901_ LFAPL 906_KEYFA
1: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity)