2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS)
1_MDLYS 6_ TPAAA 11_ LDRFV 16_ ARRLQ 21_ PRKEF 26_ VEKAR 31_ RALGA 36_ LAAAL 41_ RERGG 46_ RLGAA 51_ APRVL 56_ KTVKG 61_ GSSGR 66_ GTALK 71_ GGCDS 76_ ELVIF 81_ LDCFK 86_ SYVDQ 91_ RARRA 96_ EILSE 101_ MRASL 106_ ESWWQ 111_ NPVPG 116_ LRLTF 121_ PEQSV 126_ PGALQ 131_ FRLTS 136_ VDLED 141_ WMDVS 146_ LVPAF 151_ NVLGQ 156_ AGSGV 161_ KPKPQ 166_ VYSTL 171_ LNSGC 176_ QGGEH 181_ AACFT 186_ ELRRN 191_ FVNIR 196_ PAKLK 201_ NLILL 206_ VKHWY 211_ HQVCL 216_ QGLWK 221_ ETLPP 226_ VYALE 231_ LLTIF 236_ AWEQG 241_ CKKDA 246_ FSLAE 251_ GLRTV 256_ LGLIQ 261_ QHQHL 266_ CVFWT 271_ VNYGF 276_ EDPAV 281_ GQFLQ 286_ RQLKR 291_ PRPVI 296_ LDPAD 301_ PTWDL 306_ GNGAA 311_ WHWDL 316_ LAQEA 321_ ASCYD 326_ HPCFL 331_ RGMGD 336_ PVQSW 341_ KGPGL 346_ PRAGC 351_ SGLGH 356_ PIQLD 361_ PNQKT 366_ PENSK 371_ SLNAV 376_ YPRAG 381_ SKPPS 386_ CPAPG 391_ PTGAA 396_ SIVPS 401_ VPGMA 406_ LDLSQ 411_ IPTKE 416_ LDRFI 421_ QDHLK 426_ PSPQF 431_ QEQVK 436_ KAIDI 441_ ILRCL 446_ HENCV 451_ HKASR 456_ VSKGG 461_ SFGRG 466_ TDLRD 471_ GCDVE 476_ LIIFL 481_ NCFTD 486_ YKDQG 491_ PRRAE 496_ ILDEM 501_ RAQLE 506_ SWWQD 511_ QVPSL 516_ SLQFP 521_ EQNVP 526_ EALQF 531_ QLVST 536_ ALKSW 541_ TDVSL 546_ LPAFD 551_ AVGQL 556_ SSGTK 561_ PNPQV 566_ YSRLL 571_ TSGCQ 576_ EGEHK 581_ ACFAE 586_ LRRNF 591_ MNIRP 596_ VKLKN 601_ LILLV 606_ KHWYR 611_ QVAAQ 616_ NKGKG 621_ PAPAS 626_ LPPAY 631_ ALELL 636_ TIFAW 641_ EQGCR 646_ QDCFN 651_ MAQGF 656_ RTVLG 661_ LVQQH 666_ QQLCV 671_ YWTVN 676_ YSTED 681_ PAMRM 686_ HLLGQ 691_ LRKPR 696_ PLVLD 701_ PADPT 706_ WNVGH 711_ GSWEL 716_ LAQEA 721_ AALGM 726_ QACFL 731_ SRDGT 736_ SVQPW 741_ DVMPA 746_ LLYQT 751_ PAGDL 756_ DKFIS 761_ EFLQP 766_ NRQFL 771_ AQVNK 776_ AVDTI 781_ CSFLK 786_ ENCFR 791_ NSPIK 796_ VIKVV 801_ KGGSS 806_ AKGTA 811_ LRGRS 816_ DADLV 821_ VFLSC 826_ FSQFT 831_ EQGNK 836_ RAEII 841_ SEIRA 846_ QLEAC 851_ QQERQ 856_ FEVKF 861_ EVSKW 866_ ENPRV 871_ LSFSL 876_ TSQTM 881_ LDQSV 886_ DFDVL 891_ PAFDA 896_ LGQLV 901_ SGSRP 906_ SSQVY 911_ VDLIH 916_ SYSNA 921_ GEYST 926_ CFTEL 931_ QRDFI 936_ ISRPT 941_ KLKSL 946_ IRLVK 951_ HWYQQ 956_ CTKIS 961_ KGRGS 966_ LPPQH 971_ GLELL 976_ TVYAW 981_ EQGGK 986_ DSQFN 991_ MAEGF 996_ RTVLE 1001_ LVTQY 1006_ RQLCI 1011_ YWTIN 1016_ YNAKD 1021_ KTVGD 1026_ FLKQQ 1031_ LQKPR 1036_ PIILD 1041_ PADPT 1046_ GNLGH 1051_ NARWD 1056_ LLAKE 1061_ AAACT 1066_ SALCC 1071_ MGRNG 1076_ IPIQP 1081_WPVKA
1: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV)