NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
1_MNRHL 6_ WKSQL 11_ CEMVQ 16_ PSGGP 21_ AADQD 26_ VLGEE 31_ SPLGK 36_ PAMLH 41_ LPSEQ 46_ GAPET 51_ LQRCL 56_ EENQE 61_ LRDAI 66_ RQSNQ 71_ ILRER 76_ CEELL 81_ HFQAS 86_ QREEK 91_ EFLMC 96_ KFQEA 101_ RKLVE 106_ RLGLE 111_ KLDLK 116_ RQKEQ 121_ ALREV 126_ EHLKR 131_ CQQQM 136_ AEDKA 141_ SVKAQ 146_ VTSLL 151_ GELQE 156_ SQSRL 161_ EAATK 166_ ECQAL 171_ EGRAR 176_ AASEQ 181_ ARQLE 186_ SEREA 191_ LQQQH 196_ SVQVD 201_ QLRMQ 206_ GQSVE 211_ AALRM 216_ ERQAA 221_ SEEKR 226_ KLAQL 231_ QVAYH 236_ QLFQE 241_ YDNHI 246_ KSSVV 251_ GSERK 256_ RGMQL 261_ EDLKQ 266_ QLQQA 271_ EEALV 276_ AKQEV 281_ IDKLK 286_ EEAEQ 291_ HKIVM 296_ ETVPV 301_ LKAQA 306_ DIYKA 311_ DFQAE 316_ RQARE 321_ KLAEK 326_ KELLQ 331_ EQLEQ 336_ LQREY 341_ SKLKA 346_ SCQES 351_ ARIED 356_ MRKRH 361_ VEVSQ 366_ APLPP 371_ APAYL 376_ SSPLA 381_ LPSQR 386_ RSPPE 391_ EPPDF 396_ CCPKC 401_ QYQAP 406_ DMDTL 411_QIHVM
1: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660)
2: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B