Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
1_MMNKL 6_ YIGNL 11_ SPAVT 16_ ADDLR 21_ QLFGD 26_ RKLPL 31_ AGQVL 36_ LKSGY 41_ AFVDY 46_ PDQNW 51_ AIRAI 56_ ETLSG 61_ KVELH 66_ GKIME 71_ VDYSV 76_ SKKLR 81_ SRKIQ 86_ IRNIP 91_ PHLQW 96_ EVLDG 101_ LLAQY 106_ GTVEN 111_ VEQVN 116_ TDTET 121_ AVVNV 126_ TYATR 131_ EEAKI 136_ AMEKL 141_ SGHQF 146_ ENYSF 151_ KISYI 156_ PDEEV 161_ SSPSP 166_ PQRAQ 171_ RGDHS 176_ SREQG 181_ HAPGG 186_ TSQAR 191_ QIDFP 196_ LRILV 201_ PTQFV 206_ GAIIG 211_ KEGLT 216_ IKNIT 221_ KQTQS 226_ RVDIH 231_ RKENS 236_ GAAEK 241_ PVTIH 246_ ATPEG 251_ TSEAC 256_ RMILE 261_ IMQKE 266_ ADETK 271_ LAEEI 276_ PLKIL 281_ AHNGL 286_ VGRLI 291_ GKEGR 296_ NLKKI 301_ EHETG 306_ TKITI 311_ SSLQD 316_ LSIYN 321_ PERTI 326_ TVKGT 331_ VEACA 336_ SAEIE 341_ IMKKL 346_ REAFE 351_ NDMLA 356_ VNQQA 361_ NLIPG 366_ LNLSA 371_ LGIFS 376_ TGLSV 381_ LSPPA 386_ GPRGA 391_ PPAAP 396_ YHPFT 401_ THSGY 406_ FSSLY 411_ PHHQF 416_ GPFPH 421_ HHSYP 426_ EQEIV 431_ NLFIP 436_ TQAVG 441_ AIIGK 446_ KGAHI 451_ KQLAR 456_ FAGAS 461_ IKIAP 466_ AEGPD 471_ VSERM 476_ VIITG 481_ PPEAQ 486_ FKAQG 491_ RIFGK 496_ LKEEN 501_ FFNPK 506_ EEVKL 511_ EAHIR 516_ VPSST 521_ AGRVI 526_ GKGGK 531_ TVNEL 536_ QNLTS 541_ AEVIV 546_ PRDQT 551_ PDENE 556_ EVIVR 561_ IIGHF 566_ FASQT 571_ AQRKI 576_ REIVQ 581_ QVKQQ 586_ EQKYP 591_QGVAS
1: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152)