Zinc transporter 1 (ZnT-1) (Solute carrier family 30 member 1)
1_MGCWG 6_ RNRGR 11_ LLCML 16_ ALTFM 21_ FMVLE 26_ VVVSR 31_ VTSSL 36_ AMLSD 41_ SFHML 46_ SDVLA 51_ LVVAL 56_ VAERF 61_ ARRTH 66_ ATQKN 71_ TFGWI 76_ RAEVM 81_ GALVN 86_ AIFLT 91_ GLCFA 96_ ILLEA 101_ IERFI 106_ EPHEM 111_ QQPLV 116_ VLGVG 121_ VAGLL 126_ VNVLG 131_ LCLFH 136_ HHSGF 141_ SQDSG 146_ HGHSH 151_ GGHGH 156_ GHGLP 161_ KGPRV 166_ KSTRP 171_ GSSDI 176_ NVAPG 181_ EQGPD 186_ QEETN 191_ TLVAN 196_ TSNSN 201_ GLKLD 206_ PADPE 211_ NPRSG 216_ DTVEV 221_ QVNGN 226_ LVREP 231_ DHMEL 236_ EEDRA 241_ GQLNM 246_ RGVFL 251_ HVLGD 256_ ALGSV 261_ IVVVN 266_ ALVFY 271_ FSWKG 276_ CSEGD 281_ FCVNP 286_ CFPDP 291_ CKAFV 296_ EIINS 301_ THASV 306_ YEAGP 311_ CWVLY 316_ LDPTL 321_ CVVMV 326_ CILLY 331_ TTYPL 336_ LKESA 341_ LILLQ 346_ TVPKQ 351_ IDIRN 356_ LIKEL 361_ RNVEG 366_ VEEVH 371_ ELHVW 376_ QLAGS 381_ RIIAT 386_ AHIKC 391_ EDPTS 396_ YMEVA 401_ KTIKD 406_ VFHNH 411_ GIHAT 416_ TIQPE 421_ FASVG 426_ SKSSV 431_ VPCEL 436_ ACRTQ 441_ CALKQ 446_ CCGTL 451_ PQAPS 456_ GKDAE 461_ KTPAV 466_ SISCL 471_ ELSNN 476_ LEKKP 481_ RRTKA 486_ ENIPA 491_ VVIEI 496_ KNMPN 501_KQPES
1: Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319)