Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)
1_MERFR 6_ LEKKL 11_ PGPDE 16_ EAVVD 21_ LGKTS 26_ STVNT 31_ KFEKE 36_ ELESH 41_ RAVYI 46_ GVHVP 51_ FSKES 56_ RRRHR 61_ HRGHK 66_ HHHRR 71_ RKDKE 76_ SDKED 81_ GRESP 86_ SYDTP 91_ SQRVQ 96_ FILGT 101_ EDDDE 106_ EHIPH 111_ DLFTE 116_ MDELC 121_ YRDGE 126_ EYEWK 131_ ETARW 136_ LKFEE 141_ DVEDG 146_ GDRWS 151_ KPYVA 156_ TLSLH 161_ SLFEL 166_ RSCIL 171_ NGTVM 176_ LDMRA 181_ STLDE 186_ IADMV 191_ LDNMI 196_ ASGQL 201_ DESIR 206_ ENVRE 211_ ALLKR 216_ HHHQN 221_ EKRFT 226_ SRIPL 231_ VRSFA 236_ DIGKK 241_ HSDPH 246_ LLERN 251_ GEGLS 256_ ASRHS 261_ LRTGL 266_ SASNL 271_ SLRGE 276_ SPLSL 281_ LLGHL 286_ LPSSR 291_ AGTPA 296_ GSRCT 301_ TPVPT 306_ PQNSP 311_ PSSPS 316_ ISRLT 321_ SRSSQ 326_ ESQRQ 331_ APELL 336_ VSPAS 341_ DDIPT 346_ VVIHP 351_ PEEDL 356_ EAALK 361_ GEEQK 366_ NEENV 371_ DLTPG 376_ ILASP 381_ QSAPG 386_ NLDNS 391_ KSGEI 396_ KGNGS 401_ GGSRE 406_ NSTVD 411_ FSKVD 416_ MNFMR 421_ KIPTG 426_ AEASN 431_ VLVGE 436_ VDFLE 441_ RPIIA 446_ FVRLA 451_ PAVLL 456_ TGLTE 461_ VPVPT 466_ RFLFL 471_ LLGPA 476_ GKAPQ 481_ YHEIG 486_ RSIAT 491_ LMTDE 496_ IFHDV 501_ AYKAK 506_ DRNDL 511_ LSGID 516_ EFLDQ 521_ VTVLP 526_ PGEWD 531_ PSIRI 536_ EPPKS 541_ VPSQE 546_ KRKIP 551_ VFHNG 556_ STPTL 561_ GETPK 566_ EAAHH 571_ AGPEL 576_ QRTGR 581_ LFGGL 586_ ILDIK 591_ RKAPF 596_ FLSDF 601_ KDALS 606_ LQCLA 611_ SILFL 616_ YCACM 621_ SPVIT 626_ FGGLL 631_ GEATE 636_ GRISA 641_ IESLF 646_ GASLT 651_ GIAYS 656_ LFAGQ 661_ PLTIL 666_ GSTGP 671_ VLVFE 676_ KILYK 681_ FCRDY 686_ QLSYL 691_ SLRTS 696_ IGLWT 701_ SFLCI 706_ VLVAT 711_ DASSL 716_ VCYIT 721_ RFTEE 726_ AFAAL 731_ ICIIF 736_ IYEAL 741_ EKLFD 746_ LGETY 751_ AFNMH 756_ NNLDK 761_ LTSYS 766_ CVCTE 771_ PPNPS 776_ NETLA 781_ QWKKD 786_ NITAH 791_ NISWR 796_ NLTVS 801_ ECKKL 806_ RGVFL 811_ GSACG 816_ HHGPY 821_ IPDVL 826_ FWCVI 831_ LFFTT 836_ FFLSS 841_ FLKQF 846_ KTKRY 851_ FPTKV 856_ RSTIS 861_ DFAVF 866_ LTIVI 871_ MVTID 876_ YLVGV 881_ PSPKL 886_ HVPEK 891_ FEPTH 896_ PERGW 901_ IISPL 906_ GDNPW 911_ WTLLI 916_ AAIPA 921_ LLCTI 926_ LIFMD 931_ QQITA 936_ VIINR 941_ KEHKL 946_ KKGAG 951_ YHLDL 956_ LMVGV 961_ MLGVC 966_ SVMGL 971_ PWFVA 976_ ATVLS 981_ ISHVN 986_ SLKVE 991_ SECSA 996_ PGEQP 1001_ KFLGI 1006_ REQRV 1011_ TGLMI 1016_ FILMG 1021_ LSVFM 1026_ TSVLK 1031_ FIPMP 1036_ VLYGV 1041_ FLYMG 1046_ VSSLK 1051_ GIQLF 1056_ DRIKL 1061_ FGMPA 1066_ KHQPD 1071_ LIYLR 1076_ YVPLW 1081_ KVHIF 1086_ TVIQL 1091_ TCLVL 1096_ LWVIK 1101_ VSAAA 1106_ VVFPM 1111_ MVLAL 1116_ VFVRK 1121_ LMDLC 1126_ FTKRE 1131_ LSWLD 1136_ DLMPE 1141_ SKKKK 1146_ EDDKK 1151_ KKEKE 1156_ EAERM 1161_ LQDDD 1166_ DTVHL 1171_ PFEGG 1176_ SLLQI 1181_ PVKAL 1186_ KYSPD 1191_ KPVSV 1196_ KISFE 1201_ DEPRK 1206_KYVDA
1: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404)
2: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis