Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1)
1_MKWKH 6_ VPFLV 11_ MISLL 16_ SLSPN 21_ HLFLA 26_ QLIPD 31_ PEDVE 36_ RGNDH 41_ GTPIP 46_ TSDND 51_ DNSLG 56_ YTGSR 61_ LRQED 66_ FPPRI 71_ VEHPS 76_ DLIVS 81_ KGEPA 86_ TLNCK 91_ AEGRP 96_ TPTIE 101_ WYKGG 106_ ERVET 111_ DKDDP 116_ RSHRM 121_ LLPSG 126_ SLFFL 131_ RIVHG 136_ RKSRP 141_ DEGVY 146_ VCVAR 151_ NYLGE 156_ AVSHN 161_ ASLEV 166_ AILRD 171_ DFRQN 176_ PSDVM 181_ VAVGE 186_ PAVME 191_ CQPPR 196_ GHPEP 201_ TISWK 206_ KDGSP 211_ LDDKD 216_ ERITI 221_ RGGKL 226_ MITYT 231_ RKSDA 236_ GKYVC 241_ VGTNM 246_ VGERE 251_ SEVAE 256_ LTVLE 261_ RPSFV 266_ KRPSN 271_ LAVTV 276_ DDSAE 281_ FKCEA 286_ RGDPV 291_ PTVRW 296_ RKDDG 301_ ELPKS 306_ RYEIR 311_ DDHTL 316_ KIRKV 321_ TAGDM 326_ GSYTC 331_ VAENM 336_ VGKAE 341_ ASATL 346_ TVQEP 351_ PHFVV 356_ KPRDQ 361_ VVALG 366_ RTVTF 371_ QCEAT 376_ GNPQP 381_ AIFWR 386_ REGSQ 391_ NLLFS 396_ YQPPQ 401_ SSSRF 406_ SVSQT 411_ GDLTI 416_ TNVQR 421_ SDVGY 426_ YICQT 431_ LNVAG 436_ SIITK 441_ AYLEV 446_ TDVIA 451_ DRPPP 456_ VIRQG 461_ PVNQT 466_ VAVDG 471_ TFVLS 476_ CVATG 481_ SPVPT 486_ ILWRK 491_ DGVLV 496_ STQDS 501_ RIKQL 506_ ENGVL 511_ QIRYA 516_ KLGDT 521_ GRYTC 526_ IASTP 531_ SGEAT 536_ WSAYI 541_ EVQEF 546_ GVPVQ 551_ PPRPT 556_ DPNLI 561_ PSAPS 566_ KPEVT 571_ DVSRN 576_ TVTLS 581_ WQPNL 586_ NSGAT 591_ PTSYI 596_ IEAFS 601_ HASGS 606_ SWQTV 611_ AENVK 616_ TETSA 621_ IKGLK 626_ PNAIY 631_ LFLVR 636_ AANAY 641_ GISDP 646_ SQISD 651_ PVKTQ 656_ DVLPT 661_ SQGVD 666_ HKQVQ 671_ RELGN 676_ AVLHL 681_ HNPTV 686_ LSSSS 691_ IEVHW 696_ TVDQQ 701_ SQYIQ 706_ GYKIL 711_ YRPSG 716_ ANHGE 721_ SDWLV 726_ FEVRT 731_ PAKNS 736_ VVIPD 741_ LRKGV 746_ NYEIK 751_ ARPFF 756_ NEFQG 761_ ADSEI 766_ KFAKT 771_ LEEAP 776_ SAPPQ 781_ GVTVS 786_ KNDGN 791_ GTAIL 796_ VSWQP 801_ PPEDT 806_ QNGMV 811_ QEYKV 816_ WCLGN 821_ ETRYH 826_ INKTV 831_ DGSTF 836_ SVVIP 841_ FLVPG 846_ IRYSV 851_ EVAAS 856_ TGAGS 861_ GVKSE 866_ PQFIQ 871_ LDAHG 876_ NPVSP 881_ EDQVS 886_ LAQQI 891_ SDVVK 896_ QPAFI 901_ AGIGA 906_ ACWII 911_ LMVFS 916_ IWLYR 921_ HRKKR 926_ NGLTS 931_ TYAGI 936_ RKVPS 941_ FTFTP 946_ TVTYQ 951_ RGGEA 956_ VSSGG 961_ RPGLL 966_ NISEP 971_ AAQPW 976_ LADTW 981_ PNTGN 986_ NHNDC 991_ SISCC 996_ TAGNG 1001_ NSDSN 1006_ LTTYS 1011_ RPADC 1016_ IANYN 1021_ NQLDN 1026_ KQTNL 1031_ MLPES 1036_ TVYGD 1041_ VDLSN 1046_ KINEM 1051_ KTFNS 1056_ PNLKD 1061_ GRFVN 1066_ PSGQP 1071_ TPYAT 1076_ TQLIQ 1081_ SNLSN 1086_ NMNNG 1091_ SGDSG 1096_ EKHWK 1101_ PLGQQ 1106_ KQEVA 1111_ PVQYN 1116_ IVEQN 1121_ KLNKD 1126_ YRAND 1131_ TVPPT 1136_ IPYNQ 1141_ SYDQN 1146_ TGGSY 1151_ NSSDR 1156_ GSSTS 1161_ GSQGH 1166_ KKGAR 1171_ TPKVP 1176_ KQGGM 1181_ NWADL 1186_ LPPPP 1191_ AHPPP 1196_ HSNSE 1201_ EYNIS 1206_ VDESY 1211_ DQEMP 1216_ CPVPP 1221_ ARMYL 1226_ QQDEL 1231_ EEEED 1236_ ERGPT 1241_ PPVRG 1246_ AASSP 1251_ AAVSY 1256_ SHQST 1261_ ATLTP 1266_ SPQEE 1271_ LQPML 1276_ QDCPE 1281_ ETGHM 1286_ QHQPD 1291_ RRRQP 1296_ VSPPP 1301_ PPRPI 1306_ SPPHT 1311_ YGYIS 1316_ GPLVS 1321_ DMDTD 1326_ APEEE 1331_ EDEAD 1336_ MEVAK 1341_ MQTRR 1346_ LLLRG 1351_ LEQTP 1356_ ASSVG 1361_ DLESS 1366_ VTGSM 1371_ INGWG 1376_ SASEE 1381_ DNISS 1386_ GRSSV 1391_ SSSDG 1396_ SFFTD 1401_ ADFAQ 1406_ AVAAA 1411_ AEYAG 1416_ LKVAR 1421_ RQMQD 1426_ AAGRR 1431_ HFHAS 1436_ QCPRP 1441_ TSPVS 1446_ TDSNM 1451_ SAAVM 1456_ QKTRP 1461_ AKKLK 1466_ HQPGH 1471_ LRRET 1476_ YTDDL 1481_ PPPPV 1486_ PPPAI 1491_ KSPTA 1496_ QSKTQ 1501_ LEVRP 1506_ VVVPK 1511_ LPSMD 1516_ ARTDR 1521_ SSDRK 1526_ GSSYK 1531_ GREVL 1536_ DGRQV 1541_ VDMRT 1546_ NPGDP 1551_ REAQE 1556_ QQNDG 1561_ KGRGN 1566_ KAAKR 1571_ DLPPA 1576_ KTHLI 1581_ QEDIL 1586_ PYCRP 1591_ TFPTS 1596_ NNPRD 1601_ PSSSS 1606_ SMSSR 1611_ GSGSR 1616_ QREQA 1621_ NVGRR 1626_ NIAEM 1631_ QVLGG 1636_ YERGE 1641_ DNNEE 1646_LEETE
1: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity)