Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
1_MSGLG 6_ ENLDP 11_ LASDS 16_ RKRKL 21_ PCDTP 26_ GQGLT 31_ CSGEK 36_ RRREQ 41_ ESKYI 46_ EELAE 51_ LISAN 56_ LSDID 61_ NFNVK 66_ PDKCA 71_ ILKET 76_ VRQIR 81_ QIKEQ 86_ GKTIS 91_ NDDDV 96_ QKADV 101_ SSTGQ 106_ GVIDK 111_ DSLGP 116_ LLLQA 121_ LDGFL 126_ FVVNR 131_ DGNIV 136_ FVSEN 141_ VTQYL 146_ QYKQE 151_ DLVNT 156_ SVYNI 161_ LHEED 166_ RKDFL 171_ KNLPK 176_ STVNG 181_ VSWTN 186_ ETQRQ 191_ KSHTF 196_ NCRML 201_ MKTPH 206_ DILED 211_ INASP 216_ EMRQR 221_ YETMQ 226_ CFALS 231_ QPRAM 236_ MEEGE 241_ DLQSC 246_ MICVA 251_ RRITT 256_ GERTF 261_ PSNPE 266_ SFITR 271_ HDLSG 276_ KVVNI 281_ DTNSL 286_ RSSMR 291_ PGFED 296_ IIRRC 301_ IQRFF 306_ SLNDG 311_ QSWSQ 316_ KRHYQ 321_ EAYLN 326_ GHAET 331_ PVYRF 336_ SLADG 341_ TIVTA 346_ QTKSK 351_ LFRNP 356_ VTNDR 361_ HGFVS 366_ THFLQ 371_ REQNG 376_ YRPNP 381_ NPVGQ 386_ GIRPP 391_ MAGCN 396_ SSVGG 401_ MSMSP 406_ NQGLQ 411_ MPSSR 416_ AYGLA 421_ DPSTT 426_ GQMSG 431_ ARYGG 436_ SSNIA 441_ SLTPG 446_ PGMQS 451_ PSSYQ 456_ NNNYG 461_ LNMSS 466_ PPHGS 471_ PGLAP 476_ NQQNI 481_ MISPR 486_ NRGSP 491_ KIASH 496_ QFSPV 501_ AGVHS 506_ PMASS 511_ GNTGN 516_ HSFSS 521_ SSLSA 526_ LQAIS 531_ EGVGT 536_ SLLST 541_ LSSPG 546_ PKLDN 551_ SPNMN 556_ ITQPS 561_ KVSNQ 566_ DSKSP 571_ LGFYC 576_ DQNPV 581_ ESSMC 586_ QSNSR 591_ DHLSD 596_ KESKE 601_ SSVEG 606_ AENQR 611_ GPLES 616_ KGHKK 621_ LLQLL 626_ TCSSD 631_ DRGHS 636_ SLTNS 641_ PLDSS 646_ CKESS 651_ VSVTS 656_ PSGVS 661_ SSTSG 666_ GVSST 671_ SNMHG 676_ SLLQE 681_ KHRIL 686_ HKLLQ 691_ NGNSP 696_ AEVAK 701_ ITAEA 706_ TGKDT 711_ SSITS 716_ CGDGN 721_ VVKQE 726_ QLSPK 731_ KKENN 736_ ALLRY 741_ LLDRD 746_ DPSDA 751_ LSKEL 756_ QPQVE 761_ GVDNK 766_ MSQCT 771_ SSTIP 776_ SSSQE 781_ KDPKI 786_ KTETS 791_ EEGSG 796_ DLDNL 801_ DAILG 806_ DLTSS 811_ DFYNN 816_ SISSN 821_ GSHLG 826_ TKQQV 831_ FQGTN 836_ SLGLK 841_ SSQSV 846_ QSIRP 851_ PYNRA 856_ VSLDS 861_ PVSVG 866_ SSPPV 871_ KNISA 876_ FPMLP 881_ KQPML 886_ GGNPR 891_ MMDSQ 896_ ENYGS 901_ SMGGP 906_ NRNVT 911_ VTQTP 916_ SSGDW 921_ GLPNS 926_ KAGRM 931_ EPMNS 936_ NSMGR 941_ PGGDY 946_ NTSLP 951_ RPALG 956_ GSIPT 961_ LPLRS 966_ NSIPG 971_ ARPVL 976_ QQQQQ 981_ MLQMR 986_ PGEIP 991_ MGMGA 996_ NPYGQ 1001_ AAASN 1006_ QLGSW 1011_ PDGML 1016_ SMEQV 1021_ SHGTQ 1026_ NRPLL 1031_ RNSLD 1036_ DLVGP 1041_ PSNLE 1046_ GQSDE 1051_ RALLD 1056_ QLHTL 1061_ LSNTD 1066_ ATGLE 1071_ EIDRA 1076_ LGIPE 1081_ LVNQG 1086_ QALEP 1091_ KQDAF 1096_ QGQEA 1101_ AVMMD 1106_ QKAGL 1111_ YGQTY 1116_ PAQGP 1121_ PMQGG 1126_ FHLQG 1131_ QSPSF 1136_ NSMMN 1141_ QMNQQ 1146_ GNFPL 1151_ QGMHP 1156_ RANIM 1161_ RPRTN 1166_ TPKQL 1171_ RMQLQ 1176_ QRLQG 1181_ QQFLN 1186_ QSRQA 1191_ LELKM 1196_ ENPTA 1201_ GGAAV 1206_ MRPMM 1211_ QPQVS 1216_ SQQGF 1221_ LNAQM 1226_ VAQRS 1231_ RELLS 1236_ HHFRQ 1241_ QRVAM 1246_ MMQQQ 1251_ QQQQQ 1256_ QQQQQ 1261_ QQQQQ 1266_ QQQQQ 1271_ QQQQQ 1276_ QTQAF 1281_ SPPPN 1286_ VTASP 1291_ SMDGL 1296_ LAGPT 1301_ MPQAP 1306_ PQQFP 1311_ YQPNY 1316_ GMGQQ 1321_ PDPAF 1326_ GRVSS 1331_ PPNAM 1336_ MSSRM 1341_ GPSQN 1346_ PMMQH 1351_ PQAAS 1356_ IYQSS 1361_ EMKGW 1366_ PSGNL 1371_ ARNSS 1376_ FSQQQ 1381_ FAHQG 1386_ NPAVY 1391_ SMVHM 1396_ NGSSG 1401_ HMGQM 1406_ NMNPM 1411_ PMSGM 1416_PMGPD
1: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit