Numb-like protein (Numb-related protein) (Numb-R)
1_MSRSA 6_ AASGG 11_ PRRPE 16_ RHLPP 21_ APCGA 26_ PGPPE 31_ TCRTE 36_ PDGAG 41_ TMNKL 46_ RQSLR 51_ RRKPA 56_ YVPEA 61_ SRPHQ 66_ WQADE 71_ DAVRK 76_ GTCSF 81_ PVRYL 86_ GHVEV 91_ EESRG 96_ MHVCE 101_ DAVKK 106_ LKAMG 111_ RKSVK 116_ SVLWV 121_ SADGL 126_ RVVDD 131_ KTKDL 136_ LVDQT 141_ IEKVS 146_ FCAPD 151_ RNLDK 156_ AFSYI 161_ CRDGT 166_ TRRWI 171_ CHCFL 176_ ALKDS 181_ GERLS 186_ HAVGC 191_ AFAAC 196_ LERKQ 201_ RREKE 206_ CGVTA 211_ AFDAS 216_ RTSFA 221_ REGSF 226_ RLSGG 231_ GRPAE 236_ REAPD 241_ KKKAE 246_ AAAAP 251_ TVAPG 256_ PAQPG 261_ HVSPT 266_ PATTS 271_ PGEKG 276_ EAGTP 281_ VAAGT 286_ TAAAI 291_ PRRHA 296_ PLEQL 301_ VRQGS 306_ FRGFP 311_ ALSQK 316_ NSPFK 321_ RQLSL 326_ RLNEL 331_ PSTLQ 336_ RRTDF 341_ QVKGT 346_ VPEME 351_ PPGAG 356_ DSDSI 361_ NALCT 366_ QISSS 371_ FASAG 376_ APAPG 381_ PPPAT 386_ TGTSA 391_ WGEPS 396_ VPPAA 401_ AFQPG 406_ HKRTP 411_ SEAER 416_ WLEEV 421_ SQVAK 426_ AQQQQ 431_ QQQQQ 436_ QQQQQ 441_ QQQQQ 446_ QAASV 451_ APVPT 456_ MPPAL 461_ QPFPA 466_ PVGPF 471_ DAAPA 476_ QVAVF 481_ LPPPH 486_ MQPPF 491_ VPAYP 496_ GLGYP 501_ PMPRV 506_ PVVGI 511_ TPSQM 516_ VANAF 521_ CSAAQ 526_ LQPQP 531_ ATLLG 536_ KAGAF 541_ PPPAI 546_ PSAPG 551_ SQARP 556_ RPNGA 561_ PWPPE 566_ PAPAP 571_ APELD 576_ PFEAQ 581_ WAALE 586_ GKATV 591_ EKPSN 596_ PFSGD 601_LQKTF
1: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons