Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)
1_MREAA 6_ AALVP 11_ PPAFA 16_ VTPAA 21_ AMEEP 26_ PPPPP 31_ PPPPP 36_ PEPET 41_ ESEPE 46_ CCLAA 51_ RQEGT 56_ LGDSA 61_ CKSPE 66_ SDLED 71_ FSDET 76_ NTENL 81_ YGTSP 86_ PSTPR 91_ QMKRM 96_ STKHQ 101_ RNNVG 106_ RPASR 111_ SNLKE 116_ KMNAP 121_ NQPPH 126_ KDTGK 131_ TVENV 136_ EEYSY 141_ KQEKK 146_ IRAAL 151_ RTTER 156_ DRKKN 161_ VQCSF 166_ MLDSV 171_ GGSLP 176_ KKSIP 181_ DVDLN 186_ KPYLS 191_ LGCSN 196_ AKLPV 201_ SVPMP 206_ IARPA 211_ RQTSR 216_ TDCPA 221_ DRLKF 226_ FETLR 231_ LLLKL 236_ TSVSK 241_ KKDRE 246_ QRGQE 251_ NTSGF 256_ WLNRS 261_ NELIW 266_ LELQA 271_ WHAGR 276_ TINDQ 281_ DFFLY 286_ TARQA 291_ IPDII 296_ NEILT 301_ FKVDY 306_ GSFAF 311_ VRDRA 316_ GFNGT 321_ SVEGQ 326_ CKATP 331_ GTKIV 336_ GYSTH 341_ HEHLQ 346_ RQRVS 351_ FEQVK 356_ RIMEL 361_ LEYIE 366_ ALYPS 371_ LQALQ 376_ KDYEK 381_ YAAKD 386_ FQDRV 391_ QALCL 396_ WLNIT 401_ KDLNQ 406_ KLRIM 411_ GTVLG 416_ IKNLS 421_ DIGWP 426_ VFEIP 431_ SPRPS 436_ KGNEP 441_ EYEGD 446_ DTEGE 451_ LKELE 456_ SSTDE 461_ SEEEQ 466_ ISDPR 471_ VPEIR 476_ QPIDN 481_ SFDIQ 486_ SRDCI 491_ SKKLE 496_ RLESE 501_ DDSLG 506_ WGAPD 511_ WSTEA 516_ GFSRH 521_ CLTSI 526_ YRPFV 531_ DKALK 536_ QMGLR 541_ KLILR 546_ LHKLM 551_ DGSLQ 556_ RARIA 561_ LVKND 566_ RPVEF 571_ SEFPD 576_ PMWGS 581_ DYVQL 586_ SRTPP 591_ SSEEK 596_ CSAVS 601_ WEELK 606_ AMDLP 611_ SFEPA 616_ FLVLC 621_ RVLLN 626_ VIHEC 631_ LKLRL 636_ EQRPA 641_ GEPSL 646_ LSIKQ 651_ LVREC 656_ KEVLK 661_ GGLLM 666_ KQYYQ 671_ FMLQE 676_ VLEDL 681_ EKPDC 686_ NIDAF 691_ EEDLH 696_ KMLMV 701_ YFDYM 706_ RSWIQ 711_ MLQQL 716_ PQASH 721_ SLKNL 726_ LEEEW 731_ NFTKE 736_ ITHYI 741_ RGGEA 746_ QAGKL 751_ FCDIA 756_ GMLLK 761_ STGSF 766_ LEFGL 771_ QESCA 776_ EFWTS 781_ ADDSS 786_ ASDEI 791_ RRSVI 796_ EISRA 801_ LKELF 806_ HEARE 811_ RASKA 816_ LGFAK 821_ MLRKD 826_ LEIAA 831_ EFRLS 836_ APVRD 841_ LLDVL 846_ KSKQY 851_ VKVQI 856_ PGLEN 861_ LQMFV 866_ PDTLA 871_ EEKSI 876_ ILQLL 881_ NAAAG 886_ KDCSK 891_ DSDDV 896_ LIDAY 901_ LLLTK 906_ HGDRA 911_ RDSED 916_ SWGTW 921_ EAQPV 926_ KVVPQ 931_ VETVD 936_ TLRSM 941_ QVDNL 946_ LLVVM 951_ QSAHL 956_ TIQRK 961_ AFQQS 966_ IEGLM 971_ TLCQE 976_ QTSSQ 981_ PVIAK 986_ ALQQL 991_ KNDAL 996_ ELCNR 1001_ ISNAI 1006_ DRVDH 1011_ MFTSE 1016_ FDAEV 1021_ DESES 1026_ VTLQQ 1031_ YYREA 1036_ MIQGY 1041_ NFGFE 1046_ YHKEV 1051_ VRLMS 1056_ GEFRQ 1061_ KIGDK 1066_ YISFA 1071_ RKWMN 1076_ YVLTK 1081_ CESGR 1086_ GTRPR 1091_ WATQG 1096_ FDFLQ 1101_ AIEPA 1106_ FISAL 1111_ PEDDF 1116_ LSLQA 1121_ LMNEC 1126_ IGHVI 1131_ GKPHS 1136_ PVTGL 1141_ YLAIH 1146_ RNSPR 1151_ PMKVP 1156_ RCHSD 1161_ PPNPH 1166_ LIIPT 1171_ PEGFS 1176_ TRSMP 1181_ SDARS 1186_ HGSPA 1191_ AAAAA 1196_ AAAAV 1201_ AASRP 1206_ SPSGG 1211_ DSVLP 1216_ KSISS 1221_ AHDTR 1226_ GSSVP 1231_ ENDRL 1236_ ASIAA 1241_ ELQFR 1246_ SLSRH 1251_ SSPTE 1256_ ERDEP 1261_ AYPRG 1266_ DSSGS 1271_ TRRSW 1276_ ELRTL 1281_ ISQSK 1286_ DTASK 1291_ LGPIE 1296_ AIQKS 1301_ VRLFE 1306_ EKRYR 1311_ EMRRK 1316_ NIIGQ 1321_ VCDTP 1326_ KSYDN 1331_ VMHVG 1336_ LRKVT 1341_ FKWQR 1346_ GNKIG 1351_ EGQYG 1356_ KVYTC 1361_ ISVDT 1366_ GELMA 1371_ MKEIR 1376_ FQPND 1381_ HKTIK 1386_ ETADE 1391_ LKIFE 1396_ GIKHP 1401_ NLVRY 1406_ FGVEL 1411_ HREEM 1416_ YIFME 1421_ YCDEG 1426_ TLEEV 1431_ SRLGL 1436_ QEHVI 1441_ RLYSK 1446_ QITIA 1451_ INVLH 1456_ EHGIV 1461_ HRDIK 1466_ GANIF 1471_ LTSSG 1476_ LIKLG 1481_ DFGCS 1486_ VKLKN 1491_ NAQTM 1496_ PGEVN 1501_ STLGT 1506_ AAYMA 1511_ PEVIT 1516_ RAKGE 1521_ GHGRA 1526_ ADIWS 1531_ LGCVV 1536_ IEMVT 1541_ GKRPW 1546_ HEYEH 1551_ NFQIM 1556_ YKVGM 1561_ GHKPP 1566_ IPERL 1571_ SPEGK 1576_ DFLSH 1581_ CLESD 1586_ PKMRW 1591_ TASQL 1596_ LDHSF 1601_VKVCT
1: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6