Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog)
1_MDQPA 6_ GLQVD 11_ YVFRG 16_ VEHAV 21_ RVMVS 26_ GQVLE 31_ LEVED 36_ RMTAD 41_ QWRGE 46_ FDAGF 51_ IEDLT 56_ HKTGN 61_ FKQFN 66_ IFCHM 71_ LESAL 76_ TQSSE 81_ SVTLD 86_ LLTYT 91_ DLESL 96_ RNRKM 101_ GGRPG 106_ SLAPR 111_ SAQLN 116_ SKRYL 121_ ILIYS 126_ VEFDR 131_ IHYPL 136_ PLPYQ 141_ GKPDP 146_ VVLQG 151_ IIRSL 156_ KEELG 161_ RLQGL 166_ DGQNT 171_ RDTRE 176_ NEIWH 181_ LREQV 186_ SRLAS 191_ EKREL 196_ EAQLG 201_ RSREE 206_ ALAGR 211_ AARQE 216_ AEALR 221_ GLVRG 226_ LELEL 231_ RQERG 236_ LGHRV 241_ AGRRG 246_ QDCRR 251_ LAKEL 256_ EEAKA 261_ SERSL 266_ RARLK 271_ TLTSE 276_ LALYK 281_ RGRRT 286_ PPVQP 291_ PPTRE 296_ DRASS 301_ SRERS 306_ ASRGR 311_ GAARS 316_ SSRES 321_ GRGSR 326_ GRGRP 331_ ARPSP 336_ SPTGG 341_ RALRF 346_ DPTAF 351_ VKAKE 356_ RKQRE 361_ IQMKQ 366_ QQRNR 371_ LGSGG 376_ SGDGP 381_ SVSWS 386_ RQTQP 391_ PAALT 396_ GRGDA 401_ PNRSR 406_ NRSSS 411_ VDSFR 416_ SRCSS 421_ ASSCS 426_ DLEDF 431_ SESLS 436_ RGGHR 441_ RRGKP 446_ PSPTP 451_ WSGSN 456_ MKSPP 461_ VERSH 466_ HQKSL 471_ ANSGG 476_ WVPIK 481_ EYSSE 486_ HQAAD 491_ MAEID 496_ ARLKA 501_ LQEYM 506_NRLDM
1: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023)