Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)
1_MTNQE 6_ KWAHL 11_ SPSEF 16_ SQLQK 21_ YAEYS 26_ TKKLK 31_ DVLEE 36_ FHGNG 41_ VLAKY 46_ NPEGK 51_ QDILN 56_ QTIDF 61_ EGFKL 66_ FMKTF 71_ LEAEL 76_ PDDFT 81_ AHLFM 86_ SFSNK 91_ FPHSS 96_ PMVKS 101_ KPALL 106_ SGGLR 111_ MNKGA 116_ ITPPR 121_ TTSPA 126_ NTCSP 131_ EVIHL 136_ KDIVC 141_ YLSLL 146_ ERGRP 151_ EDKLE 156_ FMFRL 161_ YDTDG 166_ NGFLD 171_ SSELE 176_ NIISQ 181_ MMHVA 186_ EYLEW 191_ DVTEL 196_ NPILH 201_ EMMEE 206_ IDYDH 211_ DGTVS 216_ LEEWI 221_ QGGMT 226_ TIPLL 231_ VLLGL 236_ ENNVK 241_ DDGQH 246_ VWRLK 251_ HFNKP 256_ AYCNL 261_ CLNML 266_ IGVGK 271_ QGLCC 276_ SFCKY 281_ TVHER 286_ CVARA 291_ PPSCI 296_ KTYVK 301_ SKRNT 306_ DVMHH 311_ YWVEG 316_ NCPTK 321_ CDKCH 326_ KTVKC 331_ YQGLT 336_ GLHCV 341_ WCQIT 346_ LHNKC 351_ ASHLK 356_ PECDC 361_ GPLKD 366_ HILPP 371_ TTICP 376_ VVLQT 381_ LPTSG 386_ VSVPE 391_ ERQST 396_ VKKEK 401_ SGSQQ 406_ PNKVI 411_ DKNKM 416_ QRANS 421_ VTVDG 426_ QGLQV 431_ TPVPG 436_ THPLL 441_ VFVNP 446_ KSGGK 451_ QGERI 456_ YRKFQ 461_ YLLNP 466_ RQVYS 471_ LSGNG 476_ PMPGL 481_ NFFRD 486_ VPDFR 491_ VLACG 496_ GDGTV 501_ GWVLD 506_ CIEKA 511_ NVGKH 516_ PPVAI 521_ LPLGT 526_ GNDLA 531_ RCLRW 536_ GGGYE 541_ GENLM 546_ KILKD 551_ IENST 556_ EIMLD 561_ RWKFE 566_ VIPND 571_ KDEKG 576_ DPVPY 581_ SIINN 586_ YFSIG 591_ VDASI 596_ AHRFH 601_ IMREK 606_ HPEKF 611_ NSRMK 616_ NKFWY 621_ FEFGT 626_ SETFS 631_ ATCKK 636_ LHESV 641_ EIECD 646_ GVQID 651_ LINIS 656_ LEGIA 661_ ILNIP 666_ SMHGG 671_ SNLWG 676_ ESKKR 681_ RSHRR 686_ IEKKG 691_ SDKRT 696_ TVTDA 701_ KELKF 706_ ASQDL 711_ SDQLL 716_ EVVGL 721_ EGAME 726_ MGQIY 731_ TGLKS 736_ AGRRL 741_ AQCSC 746_ VVIRT 751_ SKSLP 756_ MQIDG 761_ EPWMQ 766_ TPCTI 771_ KITHK 776_ NQAPM 781_ LMGPP 786_ PKTGL 791_ FCSLV 796_KRTRN
1: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity)
2: Does not associate with membranes but has a diacylglycerol kinase activity