Scinderin (Adseverin)
1_MAREL 6_ YHEEF 11_ ARAGK 16_ QAGLQ 21_ VWRIE 26_ KLELV 31_ PVPQS 36_ AHGDF 41_ YVGDA 46_ YLVLH 51_ TAKTS 56_ RGFTY 61_ HLHFW 66_ LGKEC 71_ SQDES 76_ TAAAI 81_ FTVQM 86_ DDYLG 91_ GKPVQ 96_ NRELQ 101_ GYESN 106_ DFVSY 111_ FKGGL 116_ KYKAG 121_ GVASG 126_ LNHVL 131_ TNDLT 136_ AKRLL 141_ HVKGR 146_ RVVRA 151_ TEVPL 156_ SWDSF 161_ NKGDC 166_ FIIDL 171_ GTEIY 176_ QWCGS 181_ SCNKY 186_ ERLKA 191_ NQVAT 196_ GIRYN 201_ ERKGR 206_ SELIV 211_ VEEGS 216_ EPSEL 221_ IKVLG 226_ EKPEL 231_ PDGGD 236_ DDDII 241_ ADISN 246_ RKMAK 251_ LYMVS 256_ DASGS 261_ MRVTV 266_ VAEEN 271_ PFSMA 276_ MLLSE 281_ ECFIL 286_ DHGAA 291_ KQIFV 296_ WKGKD 301_ ANPQE 306_ RKAAM 311_ KTAEE 316_ FLQQM 321_ NYSKN 326_ TQIQV 331_ LPEGG 336_ ETPIF 341_ KQFFK 346_ DWRDK 351_ DQSDG 356_ FGKVY 361_ VTEKV 366_ AQIKQ 371_ IPFDA 376_ SKLHS 381_ SPQMA 386_ AQHNM 391_ VDDGS 396_ GKVEI 401_ WRVEN 406_ NGRIQ 411_ VDQNS 416_ YGEFY 421_ GGDCY 426_ IILYT 431_ YPRGQ 436_ IIYTW 441_ QGANA 446_ TRDEL 451_ TTSAF 456_ LTVQL 461_ DRSLG 466_ GQAVQ 471_ IRVSQ 476_ GKEPV 481_ HLLSL 486_ FKDKP 491_ LIIYK 496_ NGTSK 501_ KGGQA 506_ PAPPT 511_ RLFQV 516_ RRNLA 521_ SITRI 526_ VEVDV 531_ DANSL 536_ NSNDV 541_ FVLKL 546_ PQNSG 551_ YIWVG 556_ KGASQ 561_ EEEKG 566_ AEYVA 571_ SVLKC 576_ KTLRI 581_ QEGEE 586_ PEEFW 591_ NSLGG 596_ KKDYQ 601_ TSPLL 606_ ETQAE 611_ DHPPR 616_ LYGCS 621_ NKTGR 626_ FVIEE 631_ IPGEF 636_ TQDDL 641_ AEDDV 646_ MLLDA 651_ WEQIF 656_ IWIGK 661_ DANEV 666_ EKKES 671_ LKSAK 676_ MYLET 681_ DPSGR 686_ DKRTP 691_ IVIIK 696_ QGHEP 701_ PTFTG 706_WFLGW
1: Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009)