E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
1_MAELG 6_ ELKHM 11_ VMSFR 16_ VSELQ 21_ VLLGF 26_ AGRNK 31_ SGRKH 36_ ELLAK 41_ ALHLL 46_ KSSCA 51_ PSVQM 56_ KIKEL 61_ YRRRF 66_ PRKTL 71_ GPSDL 76_ SLLSL 81_ PPGTS 86_ PVGSP 91_ GPLAP 96_ IPPTL 101_ LAPGT 106_ LLGPK 111_ REVDM 116_ HPPLP 121_ QPVHP 126_ DVTMK 131_ PLPFY 136_ EVYGE 141_ LIRPT 146_ TLAST 151_ SSQRF 156_ EEAHF 161_ TFALT 166_ PQQVQ 171_ QILTS 176_ REVLP 181_ GAKCD 186_ YTIQV 191_ QLRFC 196_ LCETS 201_ CPQED 206_ YFPPN 211_ LFVKV 216_ NGKLC 221_ PLPGY 226_ LPPTK 231_ NGAEP 236_ KRPSR 241_ PINIT 246_ PLARL 251_ SATVP 256_ NTIVV 261_ NWSSE 266_ FGRNY 271_ SLSVY 276_ LVRQL 281_ TAGTL 286_ LQKLR 291_ AKGIR 296_ NPDHS 301_ RALIK 306_ EKLTA 311_ DPDSE 316_ VATTS 321_ LRVSL 326_ MCPLG 331_ KMRLT 336_ VPCRA 341_ LTCAH 346_ LQSFD 351_ AALYL 356_ QMNEK 361_ KPTWT 366_ CPVCD 371_ KKAPY 376_ ESLII 381_ DGLFM 386_ EILSS 391_ CSDCD 396_ EIQFM 401_ EDGSW 406_ CPMKP 411_ KKEAS 416_ EVCPP 421_ PGYGL 426_ DGLQY 431_ SPVQG 436_ GDPSE 441_ NKKKV 446_ EVIDL 451_ TIESS 456_ SDEED 461_ LPPTK 466_ KHCSV 471_ TSAAI 476_ PALPG 481_ SKGVL 486_ TSGHQ 491_ PSSVL 496_ RSPAM 501_ GTLGG 506_ DFLSS 511_ LPLHE 516_ YPPAF 521_ PLGAD 526_ IQGLD 531_ LFSFL 536_ QTESQ 541_ HYGPS 546_ VITSL 551_ DEQDA 556_ LGHFF 561_ QYRGT 566_ PSHFL 571_ GPLAP 576_ TLGSS 581_ HCSAT 586_ PAPPP 591_ GRVSS 596_ IVAPG 601_ GALRE 606_ GHGGP 611_ LPSGP 616_ SLTGC 621_RSDII
1: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376)