Bis(5'-adenosyl)-triphosphatase ENPP4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4)
1_MKLLV 6_ ILLFS 11_ GLITG 16_ FRSDS 21_ SSSLP 26_ PKLLL 31_ VSFDG 36_ FRADY 41_ LKNYE 46_ FPHLQ 51_ NFIKE 56_ GVLVE 61_ HVKNV 66_ FITKT 71_ FPNHY 76_ SIVTG 81_ LYEES 86_ HGIVA 91_ NSMYD 96_ AVTKK 101_ HFSDS 106_ NDKDP 111_ FWWNE 116_ AVPIW 121_ VTNQL 126_ QENRS 131_ SAAAM 136_ WPGTD 141_ VPIHD 146_ TISSY 151_ FMNYN 156_ SSVSF 161_ EERLN 166_ NITMW 171_ LNNSN 176_ PPVTF 181_ ATLYW 186_ EEPDA 191_ SGHKY 196_ GPEDK 201_ ENMSR 206_ VLKKI 211_ DDLIG 216_ DLVQR 221_ LKMLG 226_ LWENL 231_ NVIIT 236_ SDHGM 241_ TQCSQ 246_ DRLIN 251_ LDSCI 256_ DHSYY 261_ TLIDL 266_ SPVAA 271_ ILPKI 276_ NRTEV 281_ YNKLK 286_ NCSPH 291_ MNVYL 296_ KEDIP 301_ NRFYY 306_ QHNDR 311_ IQPII 316_ LVADE 321_ GWTIV 326_ LNESS 331_ QKLGD 336_ HGYDN 341_ SLPSM 346_ HPFLA 351_ AHGPA 356_ FHKGY 361_ KHSTI 366_ NIVDI 371_ YPMMC 376_ HILGL 381_ KPHPN 386_ NGTFG 391_ HTKCL 396_ LVDQW 401_ CINLP 406_ EAIAI 411_ VIGSL 416_ LVLTM 421_ LTCLI 426_ IIMQN 431_ RLSVP 436_ RPFSR 441_ LQLQE 446_DDDDP
1: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors