ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1)
1_MAFTN 6_ YSSLN 11_ RAQLT 16_ FEYLH 21_ TNSTT 26_ HEFLF 31_ GALAE 36_ LVDNA 41_ RDADA 46_ TRIDI 51_ YAERR 56_ EDLRG 61_ GFMLC 66_ FLDDG 71_ AGMDP 76_ SDAAS 81_ VIQFG 86_ KSAKR 91_ TPEST 96_ QIGQY 101_ GNGLK 106_ SGSMR 111_ IGKDF 116_ ILFTK 121_ KEDTM 126_ TCLFL 131_ SRTFH 136_ EEEGI 141_ DEVIV 146_ PLPTW 151_ NARTR 156_ EPVTD 161_ NVEKF 166_ AIETE 171_ LIYKY 176_ SPFRT 181_ EEEVM 186_ TQFMK 191_ IPGDS 196_ GTLVI 201_ IFNLK 206_ LMDNG 211_ EPELD 216_ IISNP 221_ RDIQM 226_ AETSP 231_ EGTKP 236_ ERRSF 241_ RAYAA 246_ VLYID 251_ PRMRI 256_ FIHGH 261_ KVQTK 266_ RLSCC 271_ LYKPR 276_ MYKYT 281_ SSRFK 286_ TRAEQ 291_ EVKKA 296_ EHVAR 301_ IAEEK 306_ AREAE 311_ SKART 316_ LEVRL 321_ GGDLT 326_ RDSRV 331_ MLRQV 336_ QNRAI 341_ TLRRE 346_ ADVKK 351_ RIKEA 356_ KQRAL 361_ KEPKE 366_ LNFVF 371_ GVNIE 376_ HRDLD 381_ GMFIY 386_ NCSRL 391_ IKMYE 396_ KVGPQ 401_ LEGGM 406_ ACGGV 411_ VGVVD 416_ VPYLV 421_ LEPTH 426_ NKQDF 431_ ADAKE 436_ YRHLL 441_ RAMGE 446_ HLAQY 451_ WKDIA 456_ IAQRG 461_ IIKFW 466_ DEFGY 471_ LSANW 476_ NQPPS 481_ SELRY 486_ KRRRA 491_ MEIPT 496_ TIQCD 501_ LCLKW 506_ RTLPF 511_ QLSSV 516_ EKDYP 521_ DTWVC 526_ SMNPD 531_ PEQDR 536_ CEASE 541_ QKQKV 546_ PLGTF 551_ RKDMK 556_ TQEEK 561_ QKQLT 566_ EKIRQ 571_ QQEKL 576_ EALQK 581_ TTPIR 586_ SQADL 591_ KKLPL 596_ EVTTR 601_ PSTEE 606_ PVRRP 611_ QRPRS 616_ PPLPA 621_ VIRNA 626_ PSRPP 631_ SLPTP 636_ RPASQ 641_ PRKAP 646_ VISST 651_ PKLPA 656_ LAARE 661_ EASTS 666_ RLLQP 671_ PEAPR 676_ KPANT 681_ LVKTA 686_ SRPAP 691_ LVQQL 696_ SPSLL 701_ PNSKS 706_ PREVP 711_ SPKVI 716_ KTPVV 721_ KKTES 726_ PIKLS 731_ PATPS 736_ RKRSV 741_ AVSDE 746_ EEVEE 751_ EAERR 756_ KERCK 761_ RGRFV 766_ VKEEK 771_ KDSNE 776_ LSDSA 781_ GEEDS 786_ ADLKR 791_ AQKDK 796_ GLHVE 801_ VRVNR 806_ EWYTG 811_ RVTAV 816_ EVGKH 821_ VVRWK 826_ VKFDY 831_ VPTDT 836_ TPRDR 841_ WVEKG 846_ SEDVR 851_ LMKPP 856_ SPEHQ 861_ SLDTQ 866_ QEGGE 871_ EEVGP 876_ VAQQA 881_ IAVAE 886_ PSTSE 891_ CLRIE 896_ PDTTA 901_ LSTNH 906_ ETIDL 911_ LVQIL 916_ RNCLR 921_ YFLPP 926_ SFPIS 931_ KKQLS 936_ AMNSD 941_ ELISF 946_ PLKEY 951_ FKQYE 956_ VGLQN 961_ LCNSY 966_ QSRAD 971_ SRAKA 976_ SEESL 981_ RTSER 986_ KLRET 991_ EEKLQ 996_ KLRTN 1001_ IVALL 1006_ QKVQE 1011_ DIDIN 1016_ TDDEL 1021_ DAYIE 1026_DLITK
1: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864)