Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)
1_MIPNG 6_ YLMFE 11_ DENFI 16_ ESSVA 21_ KLNAL 26_ RKSGQ 31_ FCDVR 36_ LQVCG 41_ HEMLA 46_ HRAVL 51_ ACCSP 56_ YLFEI 61_ FNSDS 66_ DPHGI 71_ SHVKF 76_ DDLNP 81_ EAVEV 86_ LLNYA 91_ YTAQL 96_ KADKE 101_ LVKDV 106_ YSAAK 111_ KLKMD 116_ RVKQV 121_ CGDYL 126_ LSRMD 131_ VTSCI 136_ SYRNF 141_ ASCMG 146_ DSRLL 151_ NKVDA 156_ YIQEH 161_ LLQIS 166_ EEEEF 171_ LKLPR 176_ LKLEV 181_ MLEDN 186_ VCLPS 191_ NGKLY 196_ TKVIN 201_ WVQRS 206_ IWENG 211_ DSLEE 216_ LMEEV 221_ QTLYY 226_ SADHK 231_ LLDGN 236_ LLDGQ 241_ AEVFG 246_ SDDDH 251_ IQFVQ 256_ KKPPR 261_ ENGHK 266_ QISSS 271_ STGCL 276_ SSPNA 281_ TVQSP 286_ KHEWK 291_ IVASE 296_ KTSNN 301_ TYLCL 306_ AVLDG 311_ IFCVI 316_ FLHGR 321_ NSPQS 326_ SPTST 331_ PKLSK 336_ SLSFE 341_ MQQDE 346_ LIEKP 351_ MSPMQ 356_ YARSG 361_ LGTAE 366_ MNGKL 371_ IAAGG 376_ YNREE 381_ CLRTV 386_ ECYNP 391_ HTDHW 396_ SFLAP 401_ MRTPR 406_ ARFQM 411_ AVLMG 416_ QLYVV 421_ GGSNG 426_ HSDDL 431_ SCGEM 436_ YDSNI 441_ DDWIP 446_ VPELR 451_ TNRCN 456_ AGVCA 461_ LNGKL 466_ YIVGG 471_ SDPYG 476_ QKGLK 481_ NCDVF 486_ DPVTK 491_ LWTSC 496_ APLNI 501_ RRHQS 506_ AVCEL 511_ GGYLY 516_ IIGGA 521_ ESWNC 526_ LNTVE 531_ RYNPE 536_ NNTWT 541_ LIAPM 546_ NVARR 551_ GAGVA 556_ VLNGK 561_ LFVCG 566_ GFDGS 571_ HAISC 576_ VEMYD 581_ PTRNE 586_ WKMMG 591_ NMTSP 596_ RSNAG 601_ IATVG 606_ NTIYA 611_ VGGFD 616_ GNEFL 621_ NTVEV 626_ YNLES 631_ NEWSP 636_YTKIF
1: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201)
2: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein (PubMed:23825951, PubMed:9696811). The BTB and Kelch domains are required for splicing activity (PubMed:30538201). Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF (PubMed:30538201)